276112: 西晃/[沼田周助]/[田嶋敦]/[木下誠]/Kikuchi K/Shimodera S/[友竹正人]/Ohi K/Hashimoto R/[井本逸勢]/Takeda M/[大森哲郎]/Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia./[Schizophrenia Bulletin]

著作: 西晃/[沼田周助]/[田嶋敦]/[木下誠]/Kikuchi K/Shimodera S/[友竹正人]/Ohi K/Hashimoto R/[井本逸勢]/Takeda M/[大森哲郎]/Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia./[Schizophrenia Bulletin]

ヘルプを読む

「著作」（著作（著書，論文，レター，国際会議など））は，研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです． (この情報が属するテーブルの詳細な定義を見る)

項目名の部分にマウスカーソルを置いて少し待つと，項目の簡単な説明がツールチップ表示されます．

この情報をEDB閲覧画面で開く

EID: 276112
EOID: 906987
Map: 0
LastModified: 2018年5月22日(火) 16:38:35
Operator: 大森哲郎
Avail: TRUE
Censor: 0
Owner: 沼田周助
Read: 継承
Write: 継承
Delete: 継承

種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

著者

必須

(英) Nishi Akira / (日) 西晃 / (読) にしあきら

役割任意

貢献度任意

学籍番号推奨 ****
沼田周助([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])

役割任意

貢献度任意

学籍番号推奨
田嶋敦

役割任意

貢献度任意

学籍番号推奨
木下誠

役割任意

貢献度任意

学籍番号推奨
(英) Kikuchi K

役割任意

貢献度任意

学籍番号推奨
(英) Shimodera S

役割任意

貢献度任意

学籍番号推奨
友竹正人([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.メンタルヘルス支援学])

役割任意

貢献度任意

学籍番号推奨
(英) Ohi K

役割任意

貢献度任意

学籍番号推奨
(英) Hashimoto R

役割任意

貢献度任意

学籍番号推奨
井本逸勢

役割任意

貢献度任意

学籍番号推奨
(英) Takeda M

役割任意

貢献度任意

学籍番号推奨
大森哲郎

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia.

副題

任意

要約

任意

(英) Previous studies suggest that elevated blood homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are risk factors for schizophrenia. However, the effects of gender and MTHFR C677T genotypes on blood homocysteine levels in schizophrenia have not been consistent. We first investigated whether plasma total homocysteine levels were higher in patients with schizophrenia than in controls with stratification by gender and by the MTHFR C677T genotypes in a large cohort (N = 1379). Second, we conducted a meta-analysis of association studies between blood homocysteine levels and schizophrenia separately by gender (N = 4714). Third, we performed a case-control association study between the MTHFR C677T polymorphism and schizophrenia (N = 4998) and conducted a meta-analysis of genetic association studies based on Japanese subjects (N = 10 378). Finally, we assessed the effect of plasma total homocysteine levels on schizophrenia by a mendelian randomization approach. The ANCOVA after adjustment for age demonstrated a significant effect of diagnosis on the plasma total homocysteine levels in all strata, and the subsequent meta-analysis for gender demonstrated elevated blood homocysteine levels in both male and female patients with schizophrenia although antipsychotic medication might influence the outcome. The meta-analysis of the Japanese genetic association studies demonstrated a significant association between the MTHFR C677T polymorphism and schizophrenia. The mendelian randomization analysis in the Japanese populations yielded an OR of 1.15 for schizophrenia per 1-SD increase in plasma total homocysteine. Our study suggests that increased plasma total homocysteine levels may be associated with an increased risk of schizophrenia.

キーワード

推奨

発行所

推奨

誌名

必須

Schizophrenia Bulletin(Center for Studies of Schizophrenia (US)/National Clearinghouse for Mental Health Information (US))

(pISSN: 0586-7614, eISSN: 1745-1701)

ISSN	任意	1745-1701 ISSN: 0586-7614 (pISSN: 0586-7614, eISSN: 1745-1701) Title: Schizophrenia bulletin Title(ISO): Schizophr Bull Supplier: Oxford University Press Publisher: Oxford University Press (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

必須

頁

必須

1154 1163

都市

任意

年月日

必須

2014年 9月初日

URL

任意

DOI

任意

10.1093/schbul/sbt154 (→Scopusで検索)

PMID

任意

24535549 (→Scopusで検索)

CRID

任意

WOS

任意

000344610800025

Scopus

任意

2-s2.0-84907348082

評価値

任意

被引用数

任意

指導教員

推奨

備考

任意

(英) Article.ELocationID: 10.1093/schbul/sbt154
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) OtherID: PMC4133669
(英) KeywordList.Keyword: Japanese
(英) KeywordList.Keyword: SNP
(英) KeywordList.Keyword: mendelian randomization
(英) KeywordList.Keyword: plasma homocysteine

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University