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著作: [大江 剛]/佐々井 明子/[内田 大亮]/[玉谷 哲也]/[永井 宏和]/[宮本 洋二]/Effect of soluble factors derived from oral cancer cells on the production of interferon-γ from peripheral blood mononuclear cells following stimulation with OK-432/[Oncology Reports]

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EID
273786
EOID
718431
Map
0
LastModified
2013年12月14日(土) 20:57:16
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
宮本 洋二
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
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著者 必須
  1. 大江 剛
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Sasai Akiko / (日) 佐々井 明子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 内田 大亮
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 玉谷 哲也
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 永井 宏和
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 宮本 洋二
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Effect of soluble factors derived from oral cancer cells on the production of interferon-γ from peripheral blood mononuclear cells following stimulation with OK-432
副題 任意
要約 任意

(英) The streptococcal antitumor agent OK-432 is commonly used as an immunopotentiator for immunotherapy in various types of malignant tumors including oral cancer. It has been demonstrated that OK-432 elicits an antitumor effect by stimulating immunocompetent cells, thereby inducing multiple cytokines including interferon (IFN)-γ, interleukin (IL)-2 and IL-12. Serum concentrations of IFN-γ in patients with oral cancer were examined 24 h after administration of OK-432. Serum concentrations of IFN-γ in patients with advanced cancer were significantly lower than those in patients with early cancer. These results suggested that some soluble factors produced by cancer cells may inhibit IFN-γ production with OK-432. Thus, in the present study, an in vitro simulation model was established for the immune status of patients with oral cancer by adding conditioned medium (CM) derived from oral cancer cell lines into a culture of peripheral blood mononuclear cells (PBMCs) derived from a healthy volunteer. We investigated whether soluble factors derived from oral cancer cells affected IFN-γ production from PBMCs following stimulation with OK-432. PBMCs stimulated with OK-432 produced a large amount of IFN-γ; however, both IFN-γ production and cytotoxic activity from PBMCs induced by OK-432 were inhibited by the addition of CM in a dose-dependent manner. In order to examine these inhibitory effects against IFN-γ production, the contribution of inhibitory cytokines such as IL-4, IL-6, IL-10, transforming growth factor-β and vascular endothelial growth factor was investigated. However, neutralization of these inhibitory cytokines did not recover IFN-γ production inhibited by CM. These results indicated that unknown molecules may inhibit IFN-γ production from PBMCs following stimulation with OK-432.
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誌名 必須 Oncology Reports(Ethnikon Hidryma Ereunōn (Greece))
(pISSN: 1021-335X, eISSN: 1791-2431)
ISSN 任意 1791-2431
ISSN: 1021-335X (pISSN: 1021-335X, eISSN: 1791-2431)
Title: Oncology reports
Title(ISO): Oncol Rep
Publisher: Spandidos Publications
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
巻 必須 30
号 必須 2
頁 必須 945 951
都市 任意
年月日 必須 2013年 5月 17日
URL 任意
DOI 任意 10.3892/or.2013.2480    (→Scopusで検索)
PMID 任意 23685791    (→Scopusで検索)
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  1. (英) Article.ELocationID: 10.3892/or.2013.2480

  2. (英) Article.Affiliation: Department of Oral Surgery, Subdivision of Molecular Oral Medicine, Division of Integrated Sciences of Translational Research, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8504, Japan. go.ohe@tokushima-u.ac.jp

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article