著作: [小川 博久]/[吾妻 雅彦]/[上原 久典]/[髙橋 徹行]/[西岡 安彦]/[曽根 三郎]/[泉 啓介]/Nerve growth factor derived from bronchial epithelium afer chronic mite antigen exposure contributes to airway hyperresponsiveness by inducing hyperinnervaiton, and is inhibited by in vivo siRNA./[Clinical and Experimental Allergy]
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削除する| 種別 | 必須 | 学術論文(審査論文) | |||
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| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | Peer Review | |||
| カテゴリ | 推奨 | 研究 | |||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 |
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| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) Nerve growth factor derived from bronchial epithelium afer chronic mite antigen exposure contributes to airway hyperresponsiveness by inducing hyperinnervaiton, and is inhibited by in vivo siRNA. |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Bronchial asthma is a chronic allergic airway inflammatory disease. Neurotrophins, including nerve growth factor (NGF), play an important role in the pathogenesis of asthma. However, the effects of NGF derived from epithelium on airway hyperresponsiveness (AHR) after antigen sensitization/exposure remain uncertain. In this study, we examined the role of NGF on AHR after chronic antigen exposure and the effect of inhibiting NGF by in vivo siRNA on AHR exacerbation. We generated chronic mouse models of bronchial asthma using house-dust mite antigen (Dermatophagoides pteronyssinus; Dp). NGF concentrations in bronchoalveolar lavage fluid (BALF), lung histopathology, hyperresponsiveness, and related neuronal peptides and cytokines in supernatants of lung homogenates were determined. NGF in BALF was increased in a dose- and time-dependent manner, and was expressed primarily in bronchial epithelium. Nerve fibres and substance P-positive fibres were detected in subepithelium of Dp-sensitized and challenged mice over 4 weeks of mite antigen exposure. AHR was positively correlated with NGF concentration and nerve fibre innervation. AHR, modulation of innervation, and increased substance P were inhibited by in vivo administration of siRNA that targeted NGF, although the inhibition of NGF did not affect allergic inflammation and subepithelial fibrosis. These findings suggest that NGF derived from bronchial and alveolar epithelium plays an important role in AHR after chronic exposure to mite antigen. NGF inhibition could potentially manage bronchial asthma, including AHR. |
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| キーワード | 推奨 |
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| 発行所 | 推奨 | ||||
| 誌名 | 必須 |
Clinical and Experimental Allergy(British Society for Allergy and Clinical Immunology)
(pISSN: 0954-7894, eISSN: 1365-2222)
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| 巻 | 必須 | 42 | |||
| 号 | 必須 | 3 | |||
| 頁 | 必須 | 460 470 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2012年 3月 初日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.1111/j.1365-2222.2011.03918.x (→Scopusで検索) | |||
| PMID | 任意 | 22168511 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | 000300681600014 | |||
| Scopus | 任意 | ||||
| 評価値 | 任意 | ||||
| 被引用数 | 任意 | ||||
| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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