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著作: [安井 敏之]/[上村 浩一]/Takikawa Masaya/[苛原 稔]/Hormone replacement therapy in postmenopausal women./[The Journal of Medical Investigation : JMI]

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EID
270397
EOID
878387
Map
0
LastModified
2017年12月4日(月) 14:07:02
Operator
[ADMIN]
Avail
TRUE
Censor
承認済
Owner
上村 浩一
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 安井 敏之
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 上村 浩一
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Takikawa Masaya
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 苛原 稔
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Hormone replacement therapy in postmenopausal women.

副題 任意
要約 任意

(英) Hormone replacement therapy (HRT) is effective for relieving vasomotor symptoms such as hot flash and vaginal atrophy and for preventing bone loss in postmenopausal and bilaterally ovariectomized women. However, compliance with HRT was reported to be low despite the benefits of HRT. In addition, results of several recent large-scale randomized clinical trials have demonstrated that protection from cardiovascular disease is not an indication for treatment with estrogen and progestin in postmenopausal women. Recent studies have demonstrated that low-dose HRT is safe and effective for prevention of postmenopausal bone loss. Low-dose HRT has also been shown to be effective for reducing the number and severity of hot flashes, improving vaginal atrophy, and inducing favorable changes in lipids, lipoproteins and hemostatic factors. Moreover, low-dose regimens of CEE (conjugated equine estrogen) and MPA (medroxyprogesterone acetate) result in higher rates of amenorrhea and endometrial protection compared with the conventional dose of HRT. Low-dose HRT may improve the compliance rate and may be more effective than conventional-dose HRT for reducing the risk of breast cancer. On the other hand, it has been shown that transdermal estrogen treatment reduces the incidence and severity of hot flashes and that long-term treatment with transdermally administered estrogen is effective for protection against osteoporosis. Transdermal administration of estrogen is recommended in postmenopausal women with hypertriglycemia because this treatment has little effect on lipid metabolism. The serum estradiol level was reported to be closely related to estrogenic effects on various tissues. An HRT regimen should be based on the needs of each patient. Serum estradiol levels in women should be maintained at appropriate levels for benefits and not be excessively high in order to prevent side effects. Selection of the most appropriate regimen of HRT (dose, route of administration and schedule) for the needs of the individual are important factors to increase the rate of continuation with HRT.

キーワード 推奨
  1. (英) Administration, Cutaneous
  2. (英) Atrophy
  3. (英) Breast Neoplasms
  4. (英) Estrogen Replacement Therapy
  5. (英) Estrogens, Conjugated (USP)
  6. (英) Female
  7. (英) Hot Flashes
  8. (英) Humans
  9. (英) Medroxyprogesterone Acetate
  10. (英) Osteoporosis, Postmenopausal
  11. (英) Postmenopause
  12. (英) Randomized Controlled Trials as Topic
  13. (英) Risk
  14. (英) Vagina
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: University of Tokushima
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 50
必須 3-4
必須 136 145
都市 任意
年月日 必須 2003年 8月 初日
URL 任意
DOI 任意
PMID 任意 13678382    (→Scopusで検索)
CRID 任意
Scopus 任意
機関リポジトリ 110688
researchmap 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Obstetrics and Gynecology, The University of Tokushima School of Medicine, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) NumberOfReferences: 60