269145: Komohara Yoshihiro/Takemura Kenichi/Lei Feng Xiao/[坂下直実]/Harada Mamoru/Suzuki Hiroshi/Kodama Tatsuhiko/Takeya Motohiro/Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages./[Cancer Science]

著作: Komohara Yoshihiro/Takemura Kenichi/Lei Feng Xiao/[坂下直実]/Harada Mamoru/Suzuki Hiroshi/Kodama Tatsuhiko/Takeya Motohiro/Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages./[Cancer Science]

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EID: 269145
EOID: 1066501
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LastModified: 2023年1月27日(金) 14:23:00
Operator: 三木ちひろ
Avail: TRUE
Censor: 承認済
Owner: [副研究部長]/[徳島大学.大学院医歯薬学研究部]
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種別

必須

言語

必須

英語

招待

推奨

審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

必須

(英) Komohara Yoshihiro

役割任意

貢献度任意

学籍番号推奨
(英) Takemura Kenichi

役割任意

貢献度任意

学籍番号推奨
(英) Lei Feng Xiao

役割任意

貢献度任意

学籍番号推奨
坂下直実

役割任意

貢献度任意

学籍番号推奨
(英) Harada Mamoru

役割任意

貢献度任意

学籍番号推奨
(英) Suzuki Hiroshi

役割任意

貢献度任意

学籍番号推奨
(英) Kodama Tatsuhiko

役割任意

貢献度任意

学籍番号推奨
(英) Takeya Motohiro

役割任意

貢献度任意

学籍番号推奨

題名

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(英) Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages.

副題

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要約

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(英) Class A scavenger receptors (SR-A, CD204) are highly expressed in tumor-associated macrophages (TAM). To investigate the function of SR-A in TAM, wild-type and SR-A-deficient (SR-A(-/-)) mice were injected with EL4 cells. Although these groups of mice did not differ in the numbers of infiltrating macrophages and lymphocytes and in neovascularization, SR-A(-/-) mice had delayed growth of EL4 tumors. Expression of inducible nitric oxide (NO) synthase and interferon (IFN)-gamma mRNA increased significantly in tumor tissues from SR-A(-/-) mice. Engulfment of necrotic EL4 cells induced upregulation of NO and IFN-gamma production by cultured macrophages, and production of NO and IFN-gamma increased in SR-A(-/-) macrophages in vitro. IFN-beta production by cultured macrophages was also elevated in SR-A(-/-) macrophages in vitro. These results suggested that the antitumor activity of macrophages increased in SR-A(-/-) mice because of upregulation of NO and IFN-gamma production. These data indicate an important role of SR-A in regulating TAM function by inhibiting toll-like receptor (TLR)4-IFN-beta signaling.

キーワード

推奨

(英) Animals
アポトーシス(apoptosis)
(英) Cell Proliferation
細胞質分裂(cytokinesis)
(英) Interferon-gamma
(英) Lymphoma
(英) Macrophages
(英) Mice
(英) Mice, Inbred C57BL
一酸化窒素(nitric oxide)
(英) RNA, Messenger
(英) Scavenger Receptors, Class A
(英) Up-Regulation

発行所

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誌名

必須

Cancer Science([日本癌学会])

(pISSN: 1347-9032, eISSN: 1349-7006)

ISSN	任意	1349-7006 ISSN: 1347-9032 (pISSN: 1347-9032, eISSN: 1349-7006) Title: Cancer science Title(ISO): Cancer Sci Publisher: Wiley-Blackwell (NLM Catalog) (医中誌Web) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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100

号

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頁

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2160 2166

都市

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年月日

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2009年 7月 23日

URL

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DOI

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10.1111/j.1349-7006.2009.01296.x (→Scopusで検索)

PMID

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19694752 (→Scopusで検索)

CRID

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Scopus

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2-s2.0-71049140879

researchmap

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評価値

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被引用数

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指導教員

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備考

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(英) Article.ELocationID: 10.1111/j.1349-7006.2009.01296.x
(英) Article.Affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan.
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

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