徳島大学 教育・研究者情報データベース(EDB)

1. (英) Nishio Jun

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2. (英) Iwasaki Hiroshi

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3. 坂下 直実

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4. (英) Haraoka Seiji

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5. (英) Isayama Teruto

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6. (英) Naito Masatoshi

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7. (英) Miyayama Haruhiko

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8. (英) Yamashita Yuuya

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9. (英) Kikuchi Masahiro

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(英) Undifferentiated (embryonal) sarcoma of the liver in middle-aged adults: smooth muscle differentiation determined by immunohistochemistry and electron microscopy.

(英) Undifferentiated (embryonal) sarcoma of the liver (UESL) is a rare pediatric liver malignancy that is extremely uncommon in middle-aged individuals. We studied 2 cases of UESL in middle-aged adults (1 case in a 49-year-old woman and the other in a 62-year-old man) by histology, immunohistochemistry, and electron microscopy to clarify the cellular characteristics of this peculiar tumor. One tumor showed a mixture of spindle cells, polygonal cells, and multinucleated giant cells within a myxoid matrix and also revealed focal areas of a storiform pattern in a metastatic lesion. The other tumor was composed mainly of anaplastic large cells admixed with few fibrous or spindle-shaped components and many multinucleated giant cells. In both cases, some tumor cells contained eosinophilic hyaline globules that were diastase resistant and periodic acid-Schiff positive. Immunohistochemically, the tumor cells showed positive staining for smooth muscle markers, such as desmin, alpha-smooth muscle actin, and muscle-specific actin, and also for histiocytic markers, such as alpha-1-antitrypsin, alpha-1-antichymotrypsin, and CD68. Electron microscope examination revealed thin myofilaments with focal densities and intermediate filaments in the cytoplasm of tumor cells. Our studies suggest that UESL exhibits at least a partial smooth muscle phenotype in middle-aged adults, and this specific differentiation may be more common in this age group than in children. Tumor cells of UESL with smooth muscle differentiation in middle-aged adults show phenotypic diversity comparable to those of malignant fibrous histiocytoma with myofibroblastic differentiation.

1. (英) Actins
2. (英) Antigens, CD
3. (英) Antigens, Differentiation, Myelomonocytic
4. 細胞分化(cell differentiation)
5. (英) Cell Nucleus
6. (英) Cytoplasm
7. (英) Desmin
8. (英) Endoplasmic Reticulum, Rough
9. 女性(female)
10. (英) Golgi Apparatus
11. (英) Humans
12. 免疫組織化学(immunohistochemistry)
13. (英) Liver Neoplasms
14. 男性(male)
15. (英) Microscopy, Electron
16. (英) Middle Aged
17. 平滑筋(smooth muscle)
18. (英) Neoplasms, Germ Cell and Embryonal
19. (英) Periodic Acid-Schiff Reaction
20. (英) alpha 1-Antichymotrypsin
21. (英) alpha 1-Antitrypsin

1. (英) Article.Affiliation: Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Case Reports

3. (英) Article.PublicationTypeList.PublicationType: Journal Article