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著作: Kuriwaka-Kido Rika/Kido Shinsuke/Miyatani Yuka/Ito Yuji/[近藤 剛史]/Omatsu Takashi/Dong Bingzi/[遠藤 逸朗]/[宮本 賢一]/[松本 俊夫]/Parathyroid hormone (1-34) counteracts the suppression of interleukin-11 expression by glucocorticoid in murine osteoblasts: a possible mechanism for stimulating osteoblast differentiation against glucocorticoid excess./[Endocrinology]

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EID
268578
EOID
704028
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0
LastModified
2013年8月19日(月) 20:56:00
Operator
遠藤 逸朗
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遠藤 逸朗
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kuriwaka-Kido Rika
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kido Shinsuke
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Miyatani Yuka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Ito Yuji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 近藤 剛史
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Omatsu Takashi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Dong Bingzi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 遠藤 逸朗([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.生体機能解析学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 宮本 賢一
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. 松本 俊夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Parathyroid hormone (1-34) counteracts the suppression of interleukin-11 expression by glucocorticoid in murine osteoblasts: a possible mechanism for stimulating osteoblast differentiation against glucocorticoid excess.

副題 任意
要約 任意

(英) Glucocorticoid (GC) excess causes a rapid loss of bone with a reduction in bone formation. Intermittent PTH (1-34) administration stimulates bone formation and counteracts the inhibition of bone formation by GC excess. We have previously demonstrated that mechanical strain enhances interleukin (IL)-11 gene transcription by a rapid induction of FosB expression and protein kinase C (PKC)--mediated phosphorylation of phosphorylated mothers against decapentaplegic (Smad)-1. Because IL-11 suppresses the expression of dickkopf-1 and -2 and stimulates Wnt signaling, IL-11 appears to mediate at least a part of the effect of mechanical strain on osteoblast differentiation and bone formation. The present study was undertaken to examine the effect of PTH(1-34) and GCs on IL-11 expression in murine primary osteoblasts (mPOBs). PTH(1-34) treatment of mPOBs enhanced IL-11 expression in a time- and dose-dependent manner. PTH(1-34) also stimulated FosB expression and Smad1 phosphorylation, which cooperatively stimulated IL-11 gene transcription. PTH(1-34)-induced Smad1 phosphorylation was mediated via PKC and was abrogated in mPOBs from PKC knockout mice. Dexamethasone suppressed IL-11 gene transcription enhanced by PTH(1-34) without affecting FosB expression or Smad1 phosphorylation, and dexamethasone-GC receptor complex was bound to JunD, which forms heterodimers with FosB. High doses of PTH(1-34) counteracted the effect of dexamethasone on apoptosis of mPOBs, which was blunted by neutralizing anti-IL-11 antibody or IL-11 small interfering RNA. These results demonstrate that PTH(1-34) and GCs interact to regulate IL-11 expression in parallel with osteoblast differentiation and apoptosis and suggest that PTH(1-34) and dexamethasone may regulate osteoblast differentiation and apoptosis via their effect on IL-11 expression.

キーワード 推奨
  1. (英) Alkaline Phosphatase
  2. (英) Animals
  3. (英) Apoptosis
  4. (英) Cell Differentiation
  5. (英) Cells, Cultured
  6. (英) Dexamethasone
  7. (英) Gene Expression Regulation
  8. (英) Interleukin-11
  9. (英) Mice
  10. (英) Osteoblasts
  11. (英) Osteocalcin
  12. (英) Osteoprotegerin
  13. (英) Parathyroid Hormone
  14. (英) Phosphorylation
  15. (英) Promoter Regions, Genetic
  16. (英) Protein Kinase C-delta
  17. (英) Proto-Oncogene Proteins c-fos
  18. (英) Proto-Oncogene Proteins c-jun
  19. (英) RANK Ligand
  20. (英) RNA, Messenger
  21. (英) RNA, Small Interfering
  22. (英) Receptors, Glucocorticoid
  23. (英) Signal Transduction
  24. (英) Smad1 Protein
発行所 推奨
誌名 必須 Endocrinology([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)
ISSN 任意 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 154
必須 3
必須 1156 1167
都市 任意
年月日 必須 2013年 2月 8日
URL 任意
DOI 任意 10.1210/en.2013-1915    (→Scopusで検索)
PMID 任意 23397032    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: MD, Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.

  2. (英) PublicationType: Journal Article

  3. (英) PublicationType: Research Support, Non-U.S. Gov't