267715: [湯浅志乃]/[山口治隆]/Nakanishi Yoshinori/Kawaminami Shingo/[田畑良]/Shimizu Nobuhiko/[河野光宏]/Shimizu Teruki/Miyata Junya/Nakayama Mayuko/[岸潤]/[豊田優子]/[西岡安彦]/[谷憲治]/Treatment responses and their predictors in patients with rheumatoid arthritis treated with biological agents./[The Journal of Medical Investigation : JMI]

著作: [湯浅志乃]/[山口治隆]/Nakanishi Yoshinori/Kawaminami Shingo/[田畑良]/Shimizu Nobuhiko/[河野光宏]/Shimizu Teruki/Miyata Junya/Nakayama Mayuko/[岸潤]/[豊田優子]/[西岡安彦]/[谷憲治]/Treatment responses and their predictors in patients with rheumatoid arthritis treated with biological agents./[The Journal of Medical Investigation : JMI]

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種別

必須

学術論文(審査論文)

言語

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英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

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湯浅志乃

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学籍番号推奨
山口治隆

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貢献度任意

学籍番号推奨
(英) Nakanishi Yoshinori

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貢献度任意

学籍番号推奨
(英) Kawaminami Shingo

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貢献度任意

学籍番号推奨
田畑良

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貢献度任意

学籍番号推奨
(英) Shimizu Nobuhiko

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河野光宏

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(英) Shimizu Teruki

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(英) Miyata Junya

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(英) Nakayama Mayuko

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岸潤

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貢献度任意

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豊田優子

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西岡安彦([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])

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谷憲治

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題名

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(英) Treatment responses and their predictors in patients with rheumatoid arthritis treated with biological agents.

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(英) Biological agents represent an important advancement in for the treatment of rheumatoid arthritis (RA), but there is a subset of patients who do not improve despite therapy. This study aimed to determine the efficacy of biological agents for RA and to identify clinical factors that are associated with their response. We studied 98 patients with RA who started an initiating biological agent which was selected from infliximab, etanercept, adalimumab and tociliximab at 4 medical institutions. Etanercept was the most frequently used biological agent followed by infliximab although there was a difference in the selection of the biological agents among medical institutions. We found that etanercept achieved the highest treatment response, remission rate and drug survival rate. A high disease activity in the baseline disease activity score-c-reactive protein (CRP) was shown to be a negative predictor of the treatment response, and high patient global assessment was significantly less likely to achieve a good response. At week 4, decreases in 28 swollen joint counts and CRP were useful as predictors for sustaining the efficacy up to week 48. These data demonstrate that assessments of the disease activity at baseline and the early treatment response may be useful in predicting the efficacy and drug survival rate of biological agents.

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誌名

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The Journal of Medical Investigation : JMI([徳島大学.医学部])

(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN	任意	1349-6867 ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMI Title(ISO): J Med Invest Supplier: 徳島大学 Publisher: University of Tokushima (NLM Catalog) (Webcat Plus) (医中誌Web) (J-STAGE) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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1-2

頁

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77 90

都市

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年月日

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2013年 2月初日

URL

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DOI

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10.2152/jmi.60.77 (→Scopusで検索)

PMID

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23614915 (→Scopusで検索)

CRID

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Scopus

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機関リポジトリ

111302

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指導教員

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備考

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(英) Affiliation: Department of General Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
(英) PublicationType: Journal Article

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University