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著作: Lee Su Jung/Hayashi Kunihiko/Mishra Gita/[安井 敏之]/Kubota Toshiro/Mizunuma Hideki/Independent association between age at natural menopause and hypercholesterolemia, hypertension, and diabetes mellitus: Japan nurses' health study./[Journal of Atherosclerosis and Thrombosis]

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EID
266094
EOID
819651
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2016年5月11日(水) 11:12:10
Operator
大家 隆弘
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安井 敏之
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種別 必須
言語 必須 英語
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著者 必須
  1. (英) Lee Su Jung
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  2. (英) Hayashi Kunihiko
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    学籍番号 推奨
  3. (英) Mishra Gita
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  4. 安井 敏之([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.生殖・更年期医療学]/[徳島大学.医学部.保健学科.看護学専攻.母性·小児看護学講座])
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  5. (英) Kubota Toshiro
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  6. (英) Mizunuma Hideki
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題名 必須

(英) Independent association between age at natural menopause and hypercholesterolemia, hypertension, and diabetes mellitus: Japan nurses' health study.

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(英) Menopause is considered a cardiovascular risk factor (CRF), but age at menopause (AAM) varies considerably and could affect the risk among post-menopausal women. The aim of the study was to clarify whether AAM is associated with hypertension, diabetes mellitus (DM) and hypercholesterolemia, independent of chronological age, lifestyle and hormone replacement therapy (HRT), in a sizeable number of Japanese women. A retrospective study was conducted using the baseline survey of the ongoing large prospective Japan Nurses' Health Study. The prevalence of hypertension, DM, and hypercholesterolemia of pre-menopausal and three post-menopausal AAM groups (early: <45 years, intermediate: 45-53 years, late: >53 years) was compared among 22,426 women aged 40-59 years. Daily lifestyle such as smoking, alcohol consumption, and physical activity were included. The estimated risk (odds ratio: OR) was significantly higher in post-menopausal women and linearly elevated according to the AAM groups, and the late AAM group was more likely to have hypertension, DM, or hypercholesterolemia; however, after adjustment for age, BMI (kg/m(2)), HRT and lifestyle, menopause and AAM showed a significant association with only hypercholesterolemia and the early AAM group had the highest OR (2.72 (1.93-3.82)). Menopause and AAM did not show any independent association with the risk of hypertension and DM in the fully adjusted model. Among the post-menopausal women, early menopause increased the risk for hypercholesterolemia independently. AAM can be a useful screening tool to identify women at high risk for adverse post-menopausal lipid profiles in the Japanese.

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誌名 必須 Journal of Atherosclerosis and Thrombosis(日本動脈硬化学会)
(pISSN: 1340-3478, eISSN: 1880-3873)
ISSN 任意 1880-3873
ISSN: 1340-3478 (pISSN: 1340-3478, eISSN: 1880-3873)
Title: Journal of atherosclerosis and thrombosis
Title(ISO): J Atheroscler Thromb
Supplier: 一般社団法人 日本動脈硬化学会
Publisher: Japan Atherosclerosis Society
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 20
必須 2
必須 161 169
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年月日 必須 2012年 10月 19日
URL 任意
DOI 任意 10.5551/jat.14746    (→Scopusで検索)
PMID 任意 23079582    (→Scopusで検索)
NAID 任意
WOS 任意 000317783500005
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  1. (英) Article.Affiliation: Department of Health Promotion Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. jslee@m.u-tokyo.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't