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著作: [永田 久美子]/[中村 竜也]/[藤原 慎視]/[田中 栄二]/Ultrasound modulates the inflammatory response and promotes muscle regeneration in injured muscles./[Annals of Biomedical Engineering]

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2014年2月21日(金) 11:56:06
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大家 隆弘
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田中 栄二
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨 博士課程学生による研究報告
組織 推奨
  1. 徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学(2004年4月1日〜2015年3月31日)
  2. 徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学(2004年4月1日〜)
著者 必須
  1. 永田 久美子([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 中村 竜也([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 藤原 慎視
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 田中 栄二([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Ultrasound modulates the inflammatory response and promotes muscle regeneration in injured muscles.

副題 任意
要約 任意

(英) The purpose of this study was to examine the effect of ultrasound on inflammatory skeletal muscle in vitro and in vivo. C2C12 cells were cultured in medium with or without TNF-α or IL-1β. After stimulation with cytokines, the cells received ultrasound or sham exposure. Furthermore, the tibialis anterior (TA) muscle in C57BL/6 mice injured by cardiotoxin (CTX) were dissected after a series of ultrasound treatments and examined. Exposure of C2C12 cells to ultrasound resulted in down-regulation of cyclooxygenase-2 (COX-2) mRNA and protein expression induced by TNF-α or IL-1β, and up-regulated myogenin mRNA and protein depressed by TNF-α or IL-1β. In injured TA muscle induced by CTX, ultrasound caused increase of COX-2 mRNA at 1 day after ultrasound treatment, however, at day 5, reduction of COX-2 mRNA and protein. At day 5, ultrasound caused increase of myogenin mRNA and protein, increase of fast myosin protein, and increase of paired-box transcription factor 7 positive cells. At day 7, the cross-sectional area of myofibers in the ultrasound exposure side was significantly larger than that on the control side. In conclusion, ultrasound stimulation may be a better candidate as a medical remedy to promote myogenesis in inflammatory muscle states, such as muscle injury.

(日) The purpose of this study was to examine the effect of ultrasound on inflammatory skeletal muscle in vitro and in vivo. C2C12 cells were cultured in medium with or without TNF-α or IL-1β. After stimulation with cytokines, the cells received ultrasound or sham exposure. Furthermore, the tibialis anterior (TA) muscle in C57BL/6 mice injured by cardiotoxin (CTX) were dissected after a series of ultrasound treatments and examined. Exposure of C2C12 cells to ultrasound resulted in down-regulation of cyclooxygenase-2 (COX-2) mRNA and protein expression induced by TNF-α or IL-1β, and up-regulated myogenin mRNA and protein depressed by TNF-α or IL-1β. In injured TA muscle induced by CTX, ultrasound caused increase of COX-2 mRNA at 1 day after ultrasound treatment, however, at day 5, reduction of COX-2 mRNA and protein. At day 5, ultrasound caused increase of myogenin mRNA and protein, increase of fast myosin protein, and increase of paired-box transcription factor 7 positive cells. At day 7, the cross-sectional area of myofibers in the ultrasound exposure side was significantly larger than that on the control side. In conclusion, ultrasound stimulation may be a better candidate as a medical remedy to promote myogenesis in inflammatory muscle states, such as muscle injury.

キーワード 推奨
  1. (英) Acoustics
  2. (英) Animals
  3. (英) Cell Line
  4. (英) Cobra Venoms
  5. (英) Cyclooxygenase 2
  6. (英) Gene Expression Regulation
  7. (英) Interleukin-1beta
  8. (英) Mice
  9. (英) Mice, Inbred C57BL
  10. (英) Muscle, Skeletal
  11. (英) Myogenin
  12. (英) Myositis
  13. (英) PAX7 Transcription Factor
  14. (英) RNA, Messenger
  15. (英) Regeneration
  16. (英) Tumor Necrosis Factor-alpha
発行所 推奨
誌名 必須 Annals of Biomedical Engineering(Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)
ISSN 任意 1573-9686
ISSN: 0090-6964 (pISSN: 0090-6964, eISSN: 1573-9686)
Title: Annals of biomedical engineering
Title(ISO): Ann Biomed Eng
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 41
必須 6
必須 1095 1105
都市 任意
年月日 必須 2013年 2月 6日
URL 任意
DOI 任意 10.1007/s10439-013-0757-y    (→Scopusで検索)
PMID 任意 23386031    (→Scopusで検索)
NAID 任意
WOS 任意 000318297000001
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Orthodontics and Dentofacial Orthopedics, The University of Tokushima Graduate School of Oral Sciences, 3-18-15 Kuramoto-Cho, Tokushima, 770-8504, Japan.

  2. (英) PublicationType: Journal Article