徳島大学 教育・研究者情報データベース(EDB)

1. 島袋 充生

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. (英) Kozuka Chisayo

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. (英) Taira Shin-ichiro

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Yabiku Kouichi

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Dagvasumberel Munkhbaatar

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. 石田 昌義

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. 松本 幸子

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 八木 秀介([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.地域・家庭医療学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. 福田 大受

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. (英) Yamakawa Ken

    役割	任意
    貢献度	任意
    学籍番号	推奨

11. (英) Higa Moritake

    役割	任意
    貢献度	任意
    学籍番号	推奨

12. 添木 武([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

13. (英) Yoshida Hisashi

    役割	任意
    貢献度	任意
    学籍番号	推奨

14. (英) Masuzaki Hiroaki

    役割	任意
    貢献度	任意
    学籍番号	推奨

15. 佐田 政隆([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine.

(英) The obesity epidemic is a global public health concern that increases the likelihood of morbidity and mortality of metabolic and cardiovascular disease (CVD) and threatens to reduce life expectancy around the world. The concept of the metabolic syndrome (MetS) takes into account that visceral fat plays an essential role in the development of metabolic and cardiovascular diseases. However, MetS cannot be used to assess global CVD risk but is at best one more modifiable CVD risk factor. Thus, global cardiometabolic risk (the global risk of cardiovascular disease resulting from traditional risk factors combined with the additional contribution of the metabolic syndrome and/or insulin resistance) should be considered individually. There is solid evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as MetS. Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. Also, ectopic fat deposition could be deteriorated in the heart components such as (1) circulatory and locally recruited fat, (2) intra- and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is reviewed and also discussed are potential underlying mechanisms including adipocytokine, insulin resistance and lipotoxicity. J. Med. Invest. 60: 1-14, February, 2013.

1. 肥満症(obesity)
2. インスリン抵抗性(insulin resistance)
3. (英) cardiovascular disease
4. 糖尿病(diabetes mellitus)

1. (英) Article.Affiliation: Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article