257374: [工藤保誠]/Iizuka Shinji/Yoshida Maki/Tsunematsu Takaaki/Kondo Tomoyuki/Subarnbhesaj Ajiravudh/Deraz Elsayed Mohamed/Siriwardena Samadarani Bsm/Tahara Hidetoshi/[石丸直澄]/Ogawa Ikuko/[高田隆]/Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis./[The Journal of Biological Chemistry]

著作: [工藤保誠]/Iizuka Shinji/Yoshida Maki/Tsunematsu Takaaki/Kondo Tomoyuki/Subarnbhesaj Ajiravudh/Deraz Elsayed Mohamed/Siriwardena Samadarani Bsm/Tahara Hidetoshi/[石丸直澄]/Ogawa Ikuko/[高田隆]/Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis./[The Journal of Biological Chemistry]

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EID: 257374
EOID: 663344
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LastModified: 2012年10月4日(木) 11:59:55
Operator: 工藤保誠
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種別

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学術論文(審査論文)

言語

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英語

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審査

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Peer Review

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研究

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学究種別

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組織

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著者

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工藤保誠([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])

役割任意

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学籍番号推奨
(英) Iizuka Shinji

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貢献度任意

学籍番号推奨
(英) Yoshida Maki

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学籍番号推奨
(英) Tsunematsu Takaaki

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学籍番号推奨
(英) Kondo Tomoyuki

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(英) Subarnbhesaj Ajiravudh

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貢献度任意

学籍番号推奨
(英) Deraz Elsayed Mohamed

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学籍番号推奨
(英) Siriwardena Samadarani Bsm

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学籍番号推奨
(英) Tahara Hidetoshi

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石丸直澄

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(英) Ogawa Ikuko

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高田隆([広島大学])

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題名

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(英) Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis.

副題

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要約

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(英) Matrix metalloproteinases (MMPs) are extracellular zinc-dependent endopeptidases involved in the degradation and remodeling of extracellular matrix (ECM) in physiological and pathological processes. MMPs also have a role in cell proliferation, migration, differentiation, angiogenesis and apoptosis. We previously identified cancer invasion-related factors by comparing the gene expression profiles between parent and highly invasive clone of cancer cells. Matrix metalloproteinase-13 (MMP-13) was identified as a common upregulated gene by cancer invasion-related factors. Although MMP-13 slightly promoted tumor invasion, we found that MMP-13 was involved in tumor angiogenesis. Conditioned media from MMP-13-overexpressing cells promoted capillary formation of immortalized human umbilical vein endothelial cells (HUVECs). Furthermore, treatment with recombinant MMP-13 protein enhanced capillary tube formation both in vitro and in vivo. MMP-13-promoted capillary tube formation was mediated by activation of focal adhesion kinase (FAK) and ERK. Interestingly, MMP-13 promoted the secretion of VEGF-A from fibroblasts and endothelial cells. By immunohistochemical analysis, we found a possible correlation between MMP-13 expression and the number of blood vessels in human cancer cases. In summary, these findings suggest that MMP-13 may directly and indirectly promote tumor angiogenesis.

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The Journal of Biological Chemistry([The American Society for Biochemistry and Molecular Biology])

(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN	任意	1083-351X ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X) Title: The Journal of biological chemistry Title(ISO): J Biol Chem Publisher: American Society for Biochemistry and Molecular Biology (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

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号

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都市

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年月日

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2012年 9月 19日

URL

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DOI

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10.1074/jbc.M112.373159 (→Scopusで検索)

PMID

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22992737 (→Scopusで検索)

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Scopus

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備考

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(英) Affiliation: The University of Tokushima Graduate School, Japan;
(英) PublicationType: JOURNAL ARTICLE

徳島大学教育・研究者情報データベース(EDB)

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