徳島大学 教育・研究者情報データベース(EDB)

1. 原田 雅史([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])

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2. 森田 奈緒美

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3. 宇野 昌明

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4. 里見 淳一郎

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5. 和泉 唯信([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])

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6. 浅沼 光太郎

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7. 西谷 弘

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8. 梶 龍兒

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9. 永廣 信治

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(英) Incidence and clinical correlation of intracranial hemorrhages observed by 3-tesla gradient echo T2*-weighted images following intravenous thrombolysis with recombinant tissue plasminogen activator

(英) The purpose of this study was to determine the incidence and clinical correlation of intracranial hemorrhages (ICHs) detected by 3-tesla gradient echo T(2)*-weighted images after intravenous recombinant tissue plasminogen activator (rt-PA) administration. We included 43 consecutive patients with anterior-circulation ischemia who underwent MRI studies before and after thrombolysis. Each hemorrhage was classified as a hemorrhagic infarction (HI) or parenchymal hemorrhage (PH) according to the European Cooperative Acute Stroke Study definition. The clinical outcome was defined as an improvement (> or =4-point reduction) or deterioration (> or =4-point increase) based on a comparison between the initial and the 30-day NIHSS scores. The incidence of ICHs was 58%, and the HI rate was 52%; both were higher than the rates reported in the literature. Most of the patients with HI improved clinically, and these patients had second MRAs that showed recanalization. None of the patients with PH demonstrated improvement. Three-tesla MRI may reveal a higher frequency of HI type hemorrhages than lower-field MRIs, and HI may be a predictor of good recovery by reflecting the presence of recanalization. The rate of PH in our study was low compared to other studies, probably due to the lower dosage of rt-PA.

1. (英) Acute Disease
2. (英) Aged
3. (英) Brain
4. (英) Brain Ischemia
5. (英) Cerebral Hemorrhage
6. (英) Diffusion Magnetic Resonance Imaging
7. (英) Echo-Planar Imaging
8. (英) Female
9. (英) Humans
10. (英) Image Processing, Computer-Assisted
11. (英) Injections, Intravenous
12. (英) Male
13. (英) Middle Aged
14. (英) Recombinant Proteins
15. (英) Stroke
16. (英) Thrombolytic Therapy
17. (英) Tissue Plasminogen Activator

1. (英) Article.Affiliation: Department of Medical Imaging, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan. masafumi@medsci.tokushima-u.ac.jp

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't