著作: [重永 章]/刺激応答型アミノ酸の開発とケミカルバイオロジー分野への展開/[薬学雑誌]
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種別 | 必須 | 総説·解説 | |||||||||
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言語 | 必須 | 日本語 | |||||||||
招待 | 推奨 | 依頼 | |||||||||
審査 | 推奨 | Peer Review | |||||||||
カテゴリ | 推奨 | 研究 | |||||||||
共著種別 | 推奨 | ||||||||||
学究種別 | 推奨 | ||||||||||
組織 | 推奨 |
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著者 | 必須 |
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題名 | 必須 |
(英) Development of Stimulus-responsive Amino Acids and Their Application to Chemical Biology Use (日) 刺激応答型アミノ酸の開発とケミカルバイオロジー分野への展開 |
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副題 | 任意 | ||||||||||
要約 | 任意 |
(英) An understanding of the physiological significance of peptides and proteins is indispensable in the fields of life sciences and drug development. Recently, methods for controlling peptide and protein activities using stimuli such as UV irradiation have been attracting much attention because of their potential for clarifying the physiological roles of the peptides/proteins. In this context, we have developed a stimulus-responsive amino acid that induces peptide-bond cleavage after exposure to a stimulus. Although it has previously been reported that stimulus-responsive units can respond to a specific stimulus, our stimulus-responsive amino acid is potentially applicable to any stimulus simply by changing the protective group. In this review, the design and synthesis of stimulus-responsive amino acids are described. Their applications in chemical biology, including their use for spatiotemporal control of the activity of peptides in living cells, are also reported.<br> |
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キーワード | 推奨 |
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発行所 | 推奨 | 日本薬学会 | |||||||||
誌名 | 必須 |
薬学雑誌([日本薬学会])
(pISSN: 0031-6903, eISSN: 1347-5231)
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巻 | 必須 | 132 | |||||||||
号 | 必須 | 9 | |||||||||
頁 | 必須 | 1075 1082 | |||||||||
都市 | 任意 | ||||||||||
年月日 | 必須 | 2012年 9月 1日 | |||||||||
URL | 任意 | https://tokushima-u.repo.nii.ac.jp/records/2005108 | |||||||||
DOI | 任意 | 10.1248/yakushi.132.1075 (→Scopusで検索) | |||||||||
PMID | 任意 | ||||||||||
CRID | 任意 | 1390282681105515008 | |||||||||
WOS | 任意 | ||||||||||
Scopus | 任意 | ||||||||||
機関リポジトリ | 111943 | ||||||||||
評価値 | 任意 | ||||||||||
被引用数 | 任意 | ||||||||||
指導教員 | 推奨 | ||||||||||
備考 | 任意 |