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著作: [西岡 将規]/[島田 光生]/[栗田 信浩]/[岩田 貴]/[森本 慎也]/[吉川 幸造]/[東島 潤]/[宮谷 知彦]/Gene expression profile can predict pathological response to preoperative chemoradiotherapy in rectal cancer./[Cancer Genomics & Proteomics]

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EID
251784
EOID
801044
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0
LastModified
2015年10月27日(火) 11:32:49
Operator
三木 ちひろ
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TRUE
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Owner
吉川 幸造
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種別 必須
言語 必須 英語
招待 推奨
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カテゴリ 推奨
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学究種別 推奨
組織 推奨
著者 必須
  1. 西岡 将規(->個人[發知 将規])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 島田 光生([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 栗田 信浩
    役割 任意
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    学籍番号 推奨
  4. 岩田 貴([徳島大学.教養教育院])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 森本 慎也
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 吉川 幸造([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 東島 潤
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 宮谷 知彦
    役割 任意
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    学籍番号 推奨
題名 必須

(英) Gene expression profile can predict pathological response to preoperative chemoradiotherapy in rectal cancer.

副題 任意
要約 任意

(英) Preoperative chemoradiotherapy (CRT) has been widely used to improve local control of disease and to preserve the anal sphincter in the treatment of rectal cancer. However, the response to CRT differs among individual tumors. Our purpose of this study was to identify a set of discriminating genes that can be used for characterization and prediction of response to CRT in rectal cancer. Seventeen rectal cancer patients who underwent preoperative CRT (40 Gy radiotherapy combined with S-1) were studied. Biopsy specimens were obtained from rectal cancer patients before preoperative CRT and were analyzed by focused DNA microarray (132 genes) and immunohistochemistry. Response to CRT was determined by histopathologic examination of surgically resected specimens and patients were classified as responders (grade 2 or 3) or non-responders (grade 0 or 1). Of the 17 samples, 10 were classified as responders and 7 as non-responders. Seventeen genes were differentially expressed at significant levels (p<0.05) between responders and non-responders. All genes showed higher expression in responders as compared with non-responders. The list of discriminating genes included matrix metalloproteinase- (MMP), apoptosis- (nuclear factor kappa light polypeptide gene enhancer in B-cells 2 (NFKB2), transforming growth factor beta 1 (TGFB1)), DNA repair- (topoisomerase 1 (TOP1)), and cell proliferation (integrin, beta 1 (ITGB1))-related genes. In the immunohistochemistry of MMP7, 4 responders were judged as showing overexpression of MMP7. On the other hand, none of the non-responders were judged as showing overexpression of MMP7. Gene expression patterns of diagnostic biopsies can predict pathological response to preoperative CRT with S-1 in rectal cancer.

キーワード 推奨
  1. (英) Aged
  2. (英) Aged, 80 and over
  3. (英) Antimetabolites, Antineoplastic
  4. (英) Cluster Analysis
  5. (英) Combined Modality Therapy
  6. (英) Drug Combinations
  7. (英) Female
  8. (英) Gene Expression Profiling
  9. (英) Gene Expression Regulation, Neoplastic
  10. (英) Humans
  11. 免疫組織化学(immunohistochemistry)
  12. (英) Intracellular Signaling Peptides and Proteins
  13. (英) Male
  14. (英) Matrix Metalloproteinase 7
  15. (英) Membrane Proteins
  16. (英) Middle Aged
  17. (英) Oligonucleotide Array Sequence Analysis
  18. (英) Oxonic Acid
  19. (英) Predictive Value of Tests
  20. (英) Preoperative Care
  21. (英) Prognosis
  22. (英) Radiotherapy
  23. (英) Rectal Neoplasms
  24. (英) Tegafur
発行所 推奨
誌名 必須 Cancer Genomics & Proteomics(International Institute of Anticancer Research)
(pISSN: 1109-6535, eISSN: 1790-6245)
ISSN 任意 1790-6245
ISSN: 1109-6535 (pISSN: 1109-6535, eISSN: 1790-6245)
Title: Cancer genomics & proteomics
Title(ISO): Cancer Genomics Proteomics
Publisher: International Institute of Anticancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 8
必須 2
必須 87 92
都市 任意
年月日 必須 2011年 3月 初日
URL 任意
DOI 任意
PMID 任意 21471518    (→Scopusで検索)
NAID 任意
WOS 任意 000289321800004
Scopus 任意 2-s2.0-79955005098
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  3. (英) MedlineDate: 2011 Mar-Apr