徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部.基礎科学研究部門.人間科学分野(2009年4月1日〜2016年3月31日)

1. 的場 秀樹

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Mechanism of endurance training induced mitochondrial biogenesis: Are reactive oxygen species involved?

(英) Research in the 1960s and 1970s revealed that the most important biochemical changes in skeletal muscle in response to endurance training were increases in mitochondrial function and volume (mitochondrial biogenesis). Since the 1990s, research efforts have been directed toward the elucidation of the molecular events and the related intracellular signaling pathways involved in training-induced mitochondrial biogenesis. It was recently suggested by Gomez-Cabrera et al. (2008) that reactive oxygen species (ROS) produced during exercise play a crucial role in training-induced mitochondrial biogenesis. However, this suggestion has not necessarily been supported by subsequent studies. Future studies should aim to pinpoint the sites of ROS production and the redox status in various cellular compartments under the conditions employed, and then relate the redox status to the specific signal transduction pathways activated and the final outcome of endurance training-induced mitochondrial biogenesis.

1. (英) endurance training
2. (英) mitochondrial biogenesis
3. 活性酸素(reactive oxygen species/->キーワード[活性酸素種])