徳島大学 教育・研究者情報データベース(EDB)

1. 松井 寿美佳

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2. 安井 敏之([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.生殖・更年期医療学]/[徳島大学.医学部.保健学科.看護学専攻.母性·小児看護学講座])

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3. 谷 杏奈

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4. (英) Kunimi Kotaro

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5. 上村 浩一

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6. (英) Yamamoto Satoshi

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7. 桑原 章

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8. 松崎 利也

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9. (英) Tsuchiya Naoko

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10. (英) Yuzurihara Mitsutoshi

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11. (英) Kase Yoshio

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12. 苛原 稔

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(英) Changes in insulin sensitivity during GnRH agonist treatment in premenopausal women with leiomyoma.

(英) The purpose of this study was to determine (1) the influence of estrogen deficiency induced by gonadotropin-releasing hormone (GnRH) agonist administration on insulin sensitivity as well as hormones and factors related to insulin resistance and (2) the differences in the influence for these parameters by the degree of basal insulin sensitivity. Thirty-five women diagnosed with leiomyoma were enrolled in this study. Serum levels of fasting glucose, insulin, sex steroid hormones, sex hormone-binding globulin (SHBG), vascular inflammatory markers and cytokines before and at 6months after commencement of GnRH agonist administration were examined. In all women, levels of insulin, glucose and homeostasis model assessment of insulin resistance (HOMA-IR) were not significantly changed. However, in women who had a low HOMA-IR before treatment, levels of insulin, glucose and HOMA-IR showed significant increases and total testosterone level showed a significant decrease. In women who had a high HOMA-IR, levels of insulin, HOMA-IR and SHBG were significantly decreased and levels of highly sensitive C-reactive protein, soluble intercellular adhesion molecule-1, E-selectin and monocyte chemoattractant protein-1 were significantly increased. Change in insulin sensitivity caused by GnRH agonist administration for premenopausal women with leiomyoma differs depending on baseline insulin sensitivity before treatment.

1. (英) Adult
2. (英) Antineoplastic Agents, Hormonal
3. (英) Blood Glucose
4. (英) Body Mass Index
5. (英) C-Reactive Protein
6. (英) Chemokine CCL2
7. 細胞質分裂(cytokinesis)
8. (英) E-Selectin
9. (英) Female
10. (英) Gonadotropin-Releasing Hormone
11. (英) Humans
12. インスリン(insulin)
13. インスリン抵抗性(insulin resistance)
14. (英) Intercellular Adhesion Molecule-1
15. (英) Leiomyoma
16. (英) Leuprolide
17. (英) Middle Aged
18. (英) Premenopause
19. (英) Sex Hormone-Binding Globulin
20. (英) Testosterone
21. (英) Uterine Neoplasms

1. (英) Article.Affiliation: Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. sumika87@clin.med.tokushima-u.ac.jp

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't