徳島大学 教育・研究者情報データベース(EDB)

1. 平坂 勝也

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2. (日) 河野 尚平

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3. (日) 加川 祥子

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(英) Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice

(日) 第18回徳島医学会賞受賞論文 Cbl-b欠損によるマクロファージの活性化を介した耐糖能異常

(日) Obesity is a major cause of insulin resistance and is considered a chronic low-grade inflammatory disease. Substantial evidence has accumulated in recent years that chronic infiltration and activation of macrophages in white adipose tissue underlie the obesity-related component of these insulin resistant states. In the present study, we examined the role of Cbl-b, ubiquitin ligase, in insulin action. Elderly Cbl-b-deficient mice(Cbl-b-/-mice)developed glucose intolerance and peripheral insulin resistance. Deficiency of Cbl-b gene was associated with infiltration of macrophages into the WAT and expression of cytokines, such as tumor necrosis factor-α, interleukin-6 and monocyte chemoattractant protein-1. Furthermore, Vav1, a key factor in macrophage activation, was highly phosphorylated in peritoneal Cbl-b-/-macrophages, compared with wild type macrophages, suggesting that Cbl-b deficiency induces macrophage activation. Our results suggest that Cbl-b is a negative regulator of macrophage activation, and that macrophage activation by Cbl-b deficiency, at least in part, contributes to the peripheral insulin resistance and glucose intolerance.

1. (英) Cbl-b-deficient mice
2. (英) macrophage
3. 炎症性サイトカイン(inflammatory cytokine)
4. (英) white adipose tissue
5. インスリン抵抗性(insulin resistance)