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著作: Hashimoto Hirofumi/[藤原 広明]/Kawasaki Makoto/Saito Takeshi/Shibata Minori/Otsubo Hiroki/Takei Yoshio/Ueta Yoichi/Centrally and peripherally administered ghrelin potently inhibits water intake in rats./[Endocrinology]

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EID
248757
EOID
726508
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0
LastModified
2014年3月3日(月) 16:32:48
Operator
三木 ちひろ
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TRUE
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Owner
[学科長]/[徳島大学.医学部.医学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Hashimoto Hirofumi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 藤原 広明
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kawasaki Makoto
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Saito Takeshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Shibata Minori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Otsubo Hiroki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Takei Yoshio
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Ueta Yoichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Centrally and peripherally administered ghrelin potently inhibits water intake in rats.

副題 任意
要約 任意

(英) Ghrelin is known as a potent orexigenic hormone through its action on the brain. In this study, we examined the effects of intracerebroventricular (icv) and iv injection of ghrelin on water intake, food intake, and urine volume in rats deprived of water for 24 h. Water intake that occurred after water deprivation was significantly inhibited by icv injection of ghrelin (0.1, 1, and 10 nmol/rat) in a dose-related manner, although food intake was stimulated by the hormone. The antidipsogenic effect was as potent as the orexigenic effect. Similarly, water intake was inhibited, whereas food intake was stimulated dose dependently after iv injection of ghrelin (0.1, 1, and 10 nmol/kg). The inhibition of drinking was comparable with, or even more potent than, atrial natriuretic peptide (ANP), an established antidipsogenic hormone, when administered icv, although the antidipsogenic effect lasted longer. ANP had no effect on food intake. Urine volume decreased dose relatedly after icv injection of ghrelin but not by ANP. Intravenous injection of ghrelin had no effect on urine volume. Because drinking usually occurs with feeding, food was withdrawn to remove the prandial drinking. Then the antidipsogenic effect of ghrelin became more potent than that of ANP and continued longer than when food was available. Expression of Fos was increased in the area postrema and the nucleus of the tractus solitarius by using immunohistochemistry after icv and iv injection of ghrelin. The present study convincingly showed that ghrelin is a potent antidisogenic peptide in rats.

キーワード 推奨
  1. (英) Animals
  2. (brain)
  3. (英) Dose-Response Relationship, Drug
  4. (英) Drinking
  5. (英) Eating
  6. (英) Ghrelin
  7. (英) Injections, Intravenous
  8. (英) Injections, Intraventricular
  9. (英) Male
  10. (英) Peptide Hormones
  11. (英) Proto-Oncogene Proteins c-fos
  12. (英) Rats
  13. (英) Rats, Wistar
  14. (英) Time Factors
  15. (英) Urine
発行所 推奨
誌名 必須 Endocrinology([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)
ISSN 任意 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 148
必須 4
必須 1638 1647
都市 任意
年月日 必須 2007年 1月 25日
URL 任意
DOI 任意 10.1210/en.2006-0993    (→Scopusで検索)
PMID 任意 17255209    (→Scopusで検索)
NAID 任意
WOS 任意 000244992700023
Scopus 任意 2-s2.0-33947388790
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

  2. (英) PublicationType: Comparative Study

  3. (英) PublicationType: Journal Article

  4. (英) PublicationType: Research Support, Non-U.S. Gov't