徳島大学 教育・研究者情報データベース(EDB)

1. 安井 敏之([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.生殖・更年期医療学]/[徳島大学.医学部.保健学科.看護学専攻.母性·小児看護学講座])

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. (英) Maegawa Masahiko

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. (英) Tomita Junko

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Miyatani Yuka

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Yamada Masayo

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. 上村 浩一

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. 松崎 利也

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 桑原 章

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. (英) Kamada Masaharu

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. (英) Tsuchiya Naoko

    役割	任意
    貢献度	任意
    学籍番号	推奨

11. (英) Yuzurihara Mitsutoshi

    役割	任意
    貢献度	任意
    学籍番号	推奨

12. (英) Takeda Shuichi

    役割	任意
    貢献度	任意
    学籍番号	推奨

13. 苛原 稔

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) Changes in serum cytokine concentrations during the menopausal transition.

(英) The purpose of the present study was to clarify the changes in serum concentrations of 17 cytokines in healthy women during the menopausal transition by using a multiplexed cytokine assay and to clarify the associations of these cytokines with serum estradiol concentration. Sixteen premenopausal, 54 perimenopausal and 52 postmenopausal women were enrolled in this study. Seventeen cytokines in serum samples were measured simultaneously using a Bio-Plex human cytokine 17-Plex assay. Serum IL-6 concentration showed a weak positive correlation with age (r=0.196, p<0.05). Postmenopausal women for whom less than 5 years had passed since menopause showed significant (p<0.05) increase in serum concentrations of IL-2, GM-CSF and G-CSF, while serum IL-4 concentration was significantly (p<0.05) increased in postmenopausal women for whom more than 5 years had passed since menopause. Serum estradiol concentration showed a significant negative correlation with serum IL-6 concentration and weak negative correlations with serum concentrations of IL-2, IL-8 and GM-CSF. We were able to simultaneously measure the levels of 17 cytokines using a highly sensitive cytokine assay, and we found that the changes in serum cytokine concentrations during the menopausal transition differed. We also found that serum IL-6 concentration during the menopausal transition was negatively correlated with serum estradiol concentration.

1. (英) Adult
2. (英) Aged
3. 細胞質分裂(cytokinesis)
4. (英) Estradiol
5. (英) Female
6. (英) Granulocyte Colony-Stimulating Factor
7. (英) Granulocyte-Macrophage Colony-Stimulating Factor
8. (英) Humans
9. (英) Interleukin-2
10. (英) Interleukin-4
11. (英) Interleukin-6
12. (英) Menopause
13. (英) Middle Aged

1. (英) Article.Affiliation: Department of Obstetrics and Gynecology, University of Tokushima, Kuramoto-cho 3-18-15, Tokushima 770-8503, Japan. yasui@clin.med.tokushima-u.ac.jp

2. (英) Article.PublicationTypeList.PublicationType: Evaluation Studies

3. (英) Article.PublicationTypeList.PublicationType: Journal Article