著作: Nishimura Yumiko/[小山 保夫]/Further analysis on lidocaine-induced increase in intracellular Zn2+ concentration: Cytometric model study using FluoZin-3, 5-chloromethylfluorescein, and rat thymocytes/[Natural Science Research]
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削除する| 種別 | 必須 | 学術論文(審査論文) | ||||||||||||||||||
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| 言語 | 必須 | 英語 | ||||||||||||||||||
| 招待 | 推奨 | |||||||||||||||||||
| 審査 | 推奨 | Peer Review | ||||||||||||||||||
| カテゴリ | 推奨 | 研究 | ||||||||||||||||||
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| 組織 | 推奨 |
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| 著者 | 必須 |
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| 題名 | 必須 |
(英) Further analysis on lidocaine-induced increase in intracellular Zn2+ concentration: Cytometric model study using FluoZin-3, 5-chloromethylfluorescein, and rat thymocytes |
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| 副題 | 任意 | |||||||||||||||||||
| 要約 | 任意 |
(英) Lidocaine augmented FluoZin-3 fluorescence of rat thymocytes, suggesting the increase in intracellular Zn2+ concentration. However, the mechanism for lidocaine-induced increase in the intensity of FluoZin-3 fluorescence was not elucidated. In this study, in order to reveal the mechanism, the effects of lidocaine on FluoZin-3 and 5-chloromethylfluorescein (5-CMF) fluorescence were examined under various conditions. 5-CMF fluorescence was used as a parameter for cellular content of nonprotein thiols. The lidocaine-induced augmentation of FluoZin-3 fluorescence was observed under external Ca2+- and/or Zn2+-free conditions, suggesting that lidocaine induced intracellular Zn2+ release. Lidocaine attenuated 5-CMF fluorescence, suggesting the decrease in cellular content of nonprotein thiols. Since some peptides consisting of SH-group have been proposed to store Zn2+, the decrease in nonprotein thiol content by lidocaine reduced the cellular ability to store Zn2+, leading to an increase in intracellular Zn2+ concentration. (日) Lidocaine augmented FluoZin-3 fluorescence of rat thymocytes, suggesting the increase in intracellular Zn2+ concentration. However, the mechanism for lidocaine-induced increase in the intensity of FluoZin-3 fluorescence was not elucidated. In this study, in order to reveal the mechanism, the effects of lidocaine on FluoZin-3 and 5-chloromethylfluorescein (5-CMF) fluorescence were examined under various conditions. 5-CMF fluorescence was used as a parameter for cellular content of nonprotein thiols. The lidocaine-induced augmentation of FluoZin-3 fluorescence was observed under external Ca2+- and/or Zn2+-free conditions, suggesting that lidocaine induced intracellular Zn2+ release. Lidocaine attenuated 5-CMF fluorescence, suggesting the decrease in cellular content of nonprotein thiols. Since some peptides consisting of SH-group have been proposed to store Zn2+, the decrease in nonprotein thiol content by |
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| キーワード | 推奨 |
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| 発行所 | 推奨 | 徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部(2009年4月1日〜2016年3月31日) | ||||||||||||||||||
| 誌名 | 必須 |
Natural Science Research([徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部])
(pISSN: 0914-6385)
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| 巻 | 必須 | 26 | ||||||||||||||||||
| 号 | 必須 | 2 | ||||||||||||||||||
| 頁 | 必須 | 7 10 | ||||||||||||||||||
| 都市 | 任意 | 徳島(Tokushima/[日本国]) | ||||||||||||||||||
| 年月日 | 必須 | 2012年 4月 末日 | ||||||||||||||||||
| URL | 任意 | http://repo.lib.tokushima-u.ac.jp/96861 | ||||||||||||||||||
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| CRID | 任意 | 1050001337463881984 | ||||||||||||||||||
| NAID | 110009517148 | |||||||||||||||||||
| WOS | 任意 | |||||||||||||||||||
| Scopus | 任意 | |||||||||||||||||||
| 機関リポジトリ | 96861 | |||||||||||||||||||
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| 指導教員 | 推奨 | |||||||||||||||||||
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