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著作: [中村 竜也]/[藤原 慎視]/[永田 久美子]/[桂 智子]/[犬伏 俊博]/[田中 栄二]/Low-Intensity Pulsed Ultrasound Reduces the Inflammatory Activity of Synovitis./[Annals of Biomedical Engineering]

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2014年2月21日(金) 11:52:47
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大家 隆弘
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田中 栄二
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
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学究種別 推奨
組織 推奨
  1. 徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学(2004年4月1日〜2015年3月31日)
  2. 徳島大学.病院.診療科.矯正歯科(2003年10月1日〜)
著者 必須
  1. 中村 竜也([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 藤原 慎視
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 永田 久美子([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 桂 智子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 犬伏 俊博([広島大学])
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    貢献度 任意
    学籍番号 推奨
  6. 田中 栄二([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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    学籍番号 推奨
題名 必須

(英) Low-Intensity Pulsed Ultrasound Reduces the Inflammatory Activity of Synovitis.

副題 任意
要約 任意

(英) The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) on the cell proliferation and growth of synovial membrane cells stimulated with inflammatory cytokines, and to evaluate the effectiveness of LIPUS treatment of synovitis in the knee joints of animal models for rheumatoid arthritis. The rabbit knee synovial membrane cell line, HIG-82, was cultured in medium with or without IL-1β or TNF-α. Four hours after stimulation with the cytokines, the cells received LIPUS or sham exposure. Cell proliferation and growth were then analyzed. Using MRL/lpr mice, the anti-inflammatory effects of LIPUS were also evaluated in vivo. Stimulation with proinflammatory cytokines significantly up-regulated cell proliferation which was significantly down-regulated by LIPUS exposure. In MRL/lpr mice, exposure of knee joints to LIPUS caused a significant reduction of histological damage compared to the control. Histological lesions were significantly reduced in the joints treated with LIPUS for 3 weeks. Cox-2-positive cells in the knee joints treated with LIPUS were markedly decreased compared to the control joints. Therefore, LIPUS stimulation may be a medical treatment for joint inflammatory diseases, such as synovitis.

(日) The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) on the cell proliferation and growth of synovial membrane cells stimulated with inflammatory cytokines, and to evaluate the effectiveness of LIPUS treatment of synovitis in the knee joints of animal models for rheumatoid arthritis. The rabbit knee synovial membrane cell line, HIG-82, was cultured in medium with or without IL-1β or TNF-α. Four hours after stimulation with the cytokines, the cells received LIPUS or sham exposure. Cell proliferation and growth were then analyzed. Using MRL/lpr mice, the anti-inflammatory effects of LIPUS were also evaluated in vivo. Stimulation with proinflammatory cytokines significantly up-regulated cell proliferation which was significantly down-regulated by LIPUS exposure. In MRL/lpr mice, exposure of knee joints to LIPUS caused a significant reduction of histological damage compared to the control. Histological lesions were significantly reduced in the joints treated with LIPUS for 3 weeks. Cox-2-positive cells in the knee joints treated with LIPUS were markedly decreased compared to the control joints. Therefore, LIPUS stimulation may be a medical treatment for joint inflammatory diseases, such as synovitis.

キーワード 推奨
  1. (英) Animals
  2. (英) Arthritis, Rheumatoid
  3. (英) Cell Line
  4. (英) Cyclooxygenase 2
  5. (英) Disease Models, Animal
  6. (英) Humans
  7. (英) Interleukin-1beta
  8. (英) Knee Joint
  9. (英) Male
  10. (英) Mice
  11. (英) Rabbits
  12. (英) Synovial Membrane
  13. (英) Synovitis
  14. (英) Tumor Necrosis Factor-alpha
  15. (英) Ultrasonic Therapy
発行所 推奨
誌名 必須 Annals of Biomedical Engineering(Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)
ISSN 任意 1573-9686
ISSN: 0090-6964 (pISSN: 0090-6964, eISSN: 1573-9686)
Title: Annals of biomedical engineering
Title(ISO): Ann Biomed Eng
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 39
必須 12
必須 2964 2971
都市 任意
年月日 必須 2011年 12月 末日
URL 任意
DOI 任意 10.1007/s10439-011-0408-0    (→Scopusで検索)
PMID 任意 21938555    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan.

  2. (英) PublicationType: JOURNAL ARTICLE