徳島大学 教育・研究者情報データベース(EDB)

1. (英) Miyamoto Junko

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. 松本 高広([徳島大学.先端研究推進センター.動物資源研究部門]/[徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター.動物資源研究部門])

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. (英) Shiina Hiroko

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Inoue Kazuki

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Takada Ichiro

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. (英) Ito Saya

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. (英) Itoh Johbu

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. (英) Minematsu Takeo

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. (英) Sato Takashi

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. (英) Yanase Toshihiko

    役割	任意
    貢献度	任意
    学籍番号	推奨

11. (英) Nawata Hajime

    役割	任意
    貢献度	任意
    学籍番号	推奨

12. (英) Osamura Yoshiyuki R

    役割	任意
    貢献度	任意
    学籍番号	推奨

13. (英) Kato Shigeaki

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) The pituitary function of androgen receptor constitutes a glucocorticoid production circuit.

(英) Androgen receptor (AR) mediates diverse androgen actions, particularly reproductive processes in males and females. AR-mediated androgen signaling is considered to also control metabolic processes; however, the molecular basis remains elusive. In the present study, we explored the molecular mechanism of late-onset obesity in male AR null mutant (ARKO) mice. We determined that the obesity was caused by a hypercorticoid state. The negative feedback system regulating glucocorticoid production was impaired in ARKO mice. Male and female ARKO mice exhibited hypertrophic adrenal glands and glucocorticoid overproduction, presumably due to high levels of adrenal corticotropic hormone. The pituitary glands of the ARKO males had increased expression of proopiomelanocortin and decreased expression of the glucocorticoid receptor (GR). There were no overt structural abnormalities and no alteration in the distribution of cell types in the pituitaries of male ARKO mice. Additionally, there was normal production of the other hormones within the glucocorticoid feedback system in both the pituitary and hypothalamus. In a cell line derived from pituitary glands, GR expression was under the positive control of the activated AR. Thus, this study suggests that the activated AR supports the negative feedback regulation of glucocorticoid production via up-regulation of GR expression in the pituitary gland.

1. (英) Adrenal Glands
2. (英) Adrenocorticotropic Hormone
3. (英) Animals
4. (英) Apoptosis
5. (英) Cell Line
6. 細胞増殖·分化(cell proliferation and differentiation)
7. (英) Corticosterone
8. (英) Dihydrotestosterone
9. (英) Feedback, Physiological
10. (英) Female
11. (英) Gene Expression Regulation
12. (英) Glucocorticoids
13. (英) Hypertrophy
14. (英) Hypothalamo-Hypophyseal System
15. 視床下部(hypothalamus)
16. (英) Male
17. (英) Mice
18. ノックアウトマウス(knockout mice)
19. 下垂体(pituitary gland)
20. (英) Pituitary-Adrenal System
21. (英) Receptors, Androgen
22. (英) Receptors, Glucocorticoid

1. (英) Article.Affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

4. (英) OtherID: PMC1951475