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著作: [山本 裕史]/[田村 生弥]/Hirata Yoshiko/Kato Jun/Kagota Kei-ichiro/Katsuki Shota/Yamamoto Atsushi/Kagami Yoshihiro/[鑪迫 典久]/Aquatic Toxicity and Ecological Risk Assessment of Seven Parabens/[The Science of the Total Environment]

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EID
240938
EOID
880343
Map
0
LastModified
2017年12月20日(水) 16:25:14
Operator
三木 ちひろ
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TRUE
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Owner
[学科長]/[徳島大学.総合科学部.社会創生学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 山本 裕史
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 田村 生弥(徳島大学大学院総合科学教育部地域科学専攻)
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Hirata Yoshiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kato Jun
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kagota Kei-ichiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Katsuki Shota
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Yamamoto Atsushi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Kagami Yoshihiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 鑪迫 典久([独立行政法人 国立環境研究所])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Aquatic Toxicity and Ecological Risk Assessment of Seven Parabens

副題 任意

(英) Individual and Additive Approach

要約 任意

(英) In the present study, aquatic concentrations of seven parabens were determined in urban streams highly affected by treated or untreated domestic sewage in Tokushima and Osaka, Japan. The detected highest concentrations were 670, 207, and 163ngl(-1) for methylparaben, n-propylparaben, and n-butylparaben, respectively in sampling sites with watershed area of no sewer system in Tokushima. Conventional acute/chronic toxicity tests were conducted using medaka (Oryzias latipes), Daphnia magna, and Psuedokirchneriella subcapitata for four parabens, which was consistent with our previous study on three parabens, n-butylparaben, i-butylparaben, and benzylparaben. The aquatic toxicity on fish, daphnia, and algae was weaker for the parabens with a shorter alkyl chain than those with a longer alkyl chain as predicted by their hydrophobicity. Medaka vitellogenin assays and DNA microarray analysis were carried out for methylparaben and found induction of significant vitellogenin in male medaka at 630μgl(-1) of methylparaben, while the expression levels of genes encoding proteins such as choriogenin and vitellogenin increased for concentrations at 10μgl(-1) of methylparaben. Measured environmental concentrations (MECs) of seven parabens in Tokushima and Osaka were divided by predicted no effect concentrations (PNECs) and hazard quotient (MEC/PNEC) was determined for individual parabens. The MEC/PNEC was highest for n-propylparaben and was 0.010 followed by n-butylparaben (max. of 0.0086) and methylparaben (max. of 0.0042). The sum of the MEC/PNEC for the seven parabens was 0.0049. Equivalence factors were assigned for each paraben on the basis of the toxicity of n-butylparaben for each species, and n-butylparaben equivalence was calculated for the measured environmental concentrations. The MEC/PNEC approach was also conducted for the n-butylparaben-based equivalence values. The maximum MEC/PNEC was 0.018, which is lower than the trigger level for further detailed study such as large-scale monitoring for chronic toxicity tests including full-life cycle tests for fish.

キーワード 推奨
  1. (英) Animals
  2. (英) Chlorophyta
  3. (英) Cities
  4. (英) Daphnia
  5. 遺伝子発現(gene expression)
  6. 日本(Japan)
  7. (英) Lethal Dose 50
  8. (英) Male
  9. (英) No-Observed-Adverse-Effect Level
  10. (英) Oligonucleotide Array Sequence Analysis
  11. (英) Oryzias
  12. (英) Parabens
  13. (英) Risk Assessment
  14. (英) Rivers
  15. (英) Species Specificity
  16. (英) Toxicity Tests, Acute
  17. (英) Toxicity Tests, Chronic
  18. (英) Vitellogenins
  19. (英) Water Pollutants, Chemical
発行所 推奨
誌名 必須 The Science of the Total Environment([Elsevier Science B.V.])
(pISSN: 0048-9697, eISSN: 1879-1026)
ISSN 任意 1879-1026
ISSN: 0048-9697 (pISSN: 0048-9697, eISSN: 1879-1026)
Title: The Science of the total environment
Title(ISO): Sci Total Environ
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 410-411
必須 ---
必須 102 111
都市 任意
年月日 必須 2011年 11月 1日
URL 任意
DOI 任意 10.1016/j.scitotenv.2011.09.040    (→Scopusで検索)
PMID 任意 22051549    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-80655146732
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Institute of Socio, Arts, and Sciences, Graduate School of Integrated Arts and Sciences, The University of Tokushima,1-1 Minamijosanjima-cho, Tokushima 770-8502, Japan. hiroshi@ias.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't