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著作: Suresh S. Padmanaban/Rajan Thangarasu/[堤 理恵]/New targets for old hormones: inhibins clinical role revisited./[Endocrine Journal]

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2016年9月6日(火) 14:16:33
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大家 隆弘
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堤 理恵
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言語 必須 英語
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  1. (英) Suresh S. Padmanaban
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  2. (英) Rajan Thangarasu
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  3. 堤 理恵([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
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(英) New targets for old hormones: inhibins clinical role revisited.

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(英) Inhibins are gonadal peptide hormones belonging to the transforming growth factor-β (TGF-β) superfamily that regulate the pituitary follicle stimulating hormone (FSH) secretion by negative feedback mechanisms. It is evident that the understanding of inhibins function in the hypothalamic-pituitary-gonadal axis will provide insights into physiology and pathology of the gonadal function. In recent years, a great deal of attention has been focussed on clinical relevance of measuring circulating inhibins in normal and disease state. The past few years also have witnessed the emergence and discovery of extra pituitary action of inhibins that might provide further insights into the underlying diseases like cancer especially in the reproductive axis and various other new endocrine target organs. In this review after systematic analysis of literature, we discuss briefly the known and recent advances in function of these hormones highlighting also its structure, production and mechanisms of signal transduction. Also this review discusses about the physiological relevance of inhibin association in the normal function to the development of reproductive cancers. Finally, we describe evidence from various emerging studies that inhibins make an important contribution to other physiological functions apart from reproduction which reveals new endocrine target organs of inhibins. The emerging view is inhibin participates in multiple ways to regulate the function in different cell types and still complete repertoire of its actions is under investigation.

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誌名 必須 Endocrine Journal([社団法人 日本内分泌学会])
(pISSN: 0918-8959, eISSN: 1348-4540)
ISSN 任意 1348-4540
ISSN: 0918-8959 (pISSN: 0918-8959, eISSN: 1348-4540)
Title: Endocrine journal
Title(ISO): Endocr J
Supplier: 一般社団法人 日本内分泌学会
Publisher: Japan Endocrine Sociey/Nihon Naibunpi Gakkai
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 58
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必須 223 235
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年月日 必須 2011年 4月 9日
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DOI 任意 10.1507/endocrj.K11E-098    (→Scopusで検索)
PMID 任意 21478633    (→Scopusで検索)
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WOS 任意 000290634400001
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  1. (英) Article.Affiliation: Centre for Biomedical Research, Vellore Institute of Technology (VIT) University, Vellore, India. surepadman@rediffmail.com

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article