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著作: [原田 雅史]/[久保 均]/[能勢 歩美]/[西谷 弘]/Matsuda Tsuyoshi/Measurement of variation in the human cerebral GABA level by in vivo MEGA-editing proton MR spectroscopy using a clinical 3 T instrument and its dependence on brain region and the female menstrual cycle./[Human Brain Mapping]

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EID
236801
EOID
715208
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0
LastModified
2013年11月6日(水) 11:22:45
Operator
三木 ちひろ
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Owner
原田 雅史
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
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著者 必須
  1. 原田 雅史([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 久保 均
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 能勢 歩美([徳島大学.病院.診療科.放射線科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 西谷 弘
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Matsuda Tsuyoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Measurement of variation in the human cerebral GABA level by in vivo MEGA-editing proton MR spectroscopy using a clinical 3 T instrument and its dependence on brain region and the female menstrual cycle.
副題 任意
要約 任意

(英) The objectives of this study were to examine the reproducibility of the MEGA-editing J-difference technique and to determine the normal variation in the γ-aminobutyric acid (GABA) level depending on the cerebral region and its fluctuation according to the menstrual cycle as baseline data for clinical application. The participants consisted of 15 normal adult volunteers (eight men and seven women), and all measurements were repeated twice in all participants. The MEGA-editing pulses were incorporated into point-resolved spectroscopy on a 3 T instrument to obtain the J-difference editing spectra from a voxel located in the lentiform nuclei (LN), left frontal lobe (FL), and anterior cingulate cortex (AC). The GABA levels in the gray matter (GM) were compensated by the fraction ratios of the gray and white matters and cerebrospinal fluid in the measurement volume. The extent of the variation in GABA was almost the same as that observed in the major metabolites, and its reproducibility was also maintained (intraclass correlation coefficient > 0.7). GABA level was highest in LN and lowest in AC. A difference in the GABA level between the follicular and luteal phases of the menstrual cycle was found in both LN and FL, but not in AC. This technique showed the differences in the GABA levels in the GM and the region-specific decrease in the GABA levels during the women's luteal phase.
キーワード 推奨
  1. (英) Brain Chemistry
  2. (英) Brain Mapping
  3. (英) Cerebral Cortex
  4. (英) Female
  5. (英) Humans
  6. (英) Image Interpretation, Computer-Assisted
  7. (英) Magnetic Resonance Spectroscopy
  8. (英) Male
  9. (英) Menstrual Cycle
  10. (英) Protons
  11. (英) Reproducibility of Results
  12. (英) Young Adult
  13. (英) gamma-Aminobutyric Acid
発行所 推奨
誌名 必須 Human Brain Mapping([Wiley-Liss, Inc.])
(pISSN: 1065-9471, eISSN: 1097-0193)
ISSN 任意 1097-0193
ISSN: 1065-9471 (pISSN: 1065-9471, eISSN: 1097-0193)
Title: Human brain mapping
Title(ISO): Hum Brain Mapp
Publisher: Wiley
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
巻 必須 32
号 必須 5
頁 必須 828 833
都市 任意
年月日 必須 2011年 5月 初日
URL 任意
DOI 任意 10.1002/hbm.21086    (→Scopusで検索)
PMID 任意 20645307    (→Scopusで検索)
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Scopus 任意
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指導教員 推奨
備考 任意

  1. (英) Article.ELocationID: 10.1002/hbm.21086

  2. (英) Article.Affiliation: Department of Medical Imaging, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Japan. masafumi@medsci.tokushima-u.ac.jp

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't