徳島大学 教育・研究者情報データベース(EDB)

1. 内藤 毅

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2. (英) Shiota H

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3. (英) Mimura Y

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(英) Side effects in the treatment of herpetic keratitis.

(英) Various side effects due to antiherpetic drugs observed in the last ten years in our department were studied. A total of 132 patients were treated with 5-iodo-2'-deoxyuridine (IDU), 69 with trifluorothymidine (F3T), 58 with acyclovir (ACV) and 33 with adenine arabinoside (ara-A). Patch tests were routinely done when patients exhibited contact dermatitis. Of the patients treated with IDU, 3 (2.3%) showed contact dermatitis, 2 (1.5%) follicular conjunctivitis and 1 (0.8%) punctate keratopathy. Of the patients treated with F3T, 7 (10.1%) exhibited contact dermatitis and 1 (1.4%) follicular conjunctivitis. In the group treated with ACV, 2 (3.4%) patients showed punctate keratopathy. The patients who received ara-A did not show any side effects. We found that F3T caused contact dermatitis more frequently in Japanese people than Europeans. These side effects were resolved by switching to another anti-herpetic drug without the occurrence of cross-allergy. Therefore, switching to another drug is strongly recommended when patients exhibit side effects in the treatment of herpetic keratitis. Other complications were allergy to atropine and to drug preservative.

1. (英) Acyclovir
2. (英) Conjunctivitis
3. (英) Corneal Diseases
4. (英) Dermatitis, Contact
5. (英) Humans
6. (英) Idoxuridine
7. (英) Keratitis, Dendritic
8. (英) Thymidine
9. (英) Trifluridine
10. (英) Vidarabine

1. (英) Article.PublicationTypeList.PublicationType: Journal Article