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著作: [西村 明儒]/Are lectin positive spherical deposits detected in the molecular layer of the hippocampal formation related with neuronal apoptosis?/[The Journal of Medical Investigation : JMI]

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EID
234497
EOID
877470
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LastModified
2017年12月4日(月) 13:57:44
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西村 明儒
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種別 必須
言語 必須 英語
招待 推奨
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カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 西村 明儒([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.法医学])
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(英) Are lectin positive spherical deposits detected in the molecular layer of the hippocampal formation related with neuronal apoptosis?

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(英) Previously, multi-lectin positive spherical shaped deposits were detected in the hippocampal formation of degenerative demented and schizophrenic brains and reported they possessed some possibility as a predominant tool of postmortem diagnosis, more detected in schizophrenia cases than age-matched control cases. Multi-fluorescent immunohistochemical and lectin histochemical method and immuno electron microscope method were performed on 51 forensic autopsied brains containing 16 cases of schizophrenia. In multi-fluorescent staining, partial disrupted nucleus with decreased staining properties by mean of SYBR green were detected, and lectin and single strand DNA were co-stained in the portion of partial disrupted nucleus. In immuno electron microscope method, lectin positive structures were also detected in the portion of partial disrupted nucleus. These neurons were suspected in the process of apoptosis by their distinguishable features. Some experimental studies were reported that a kind of therapeutic products of major tranquillizers induced neuron apoptosis in dentate gyrus. As the lectin positive spherical shaped deposits were detected in not only 5 schizophrenia cases without drug treatment but also in 11 schizophrenia cases with drug treatment in this study, they might be detected as the intrinsic pathological change of schizophrenia. The lectin positive spherical shaped deposits detected in the hippocampal formation were suspected as the histopathological marker of the postmortem diagnosis for schizophrenia. Further examination for specifying group of neurons detected them in and initiated apoptosis are necessitated.

キーワード 推奨
  1. (英) Adult
  2. (英) Aged
  3. (英) Aged, 80 and over
  4. (英) Alzheimer Disease
  5. (英) Apoptosis
  6. (英) Case-Control Studies
  7. (英) Cytoplasmic Structures
  8. (英) Diagnosis
  9. (英) Down Syndrome
  10. (英) Female
  11. (英) Fluorescent Dyes
  12. (英) Hippocampus
  13. (英) Humans
  14. (英) Lectins
  15. (英) Male
  16. (英) Microscopy, Fluorescence
  17. (英) Microscopy, Immunoelectron
  18. (英) Middle Aged
  19. (英) Neurons
  20. (英) Schizophrenia
  21. (英) Young Adult
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 57
必須 3-4
必須 183 190
都市 任意
年月日 必須 2010年 8月 初日
URL 任意
DOI 任意 10.2152/jmi.57.183    (→Scopusで検索)
PMID 任意 20847517    (→Scopusで検索)
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Scopus 任意
機関リポジトリ 79154
評価値 任意
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指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokusshima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Review