徳島大学 教育・研究者情報データベース(EDB)

1. (英) Sakata-Yanagimoto Mamiko

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2. (英) Sakai Toru

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3. (英) Miyake Yasuyuki

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4. (英) Saito I. Toshiki

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5. (英) Maruyama Haruhiko

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6. (英) Morishita Yasuyuki

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7. (英) Nakagami-Yamaguchi Etsuko

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8. (英) Kumano Keiki

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9. (英) Yagita Hideo

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10. (英) Fukayama Masashi

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11. (英) Ogawa Seishi

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12. (英) Kurokawa Mineo

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13. 安友 康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

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14. (英) Chiba Shigeru

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(英) Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.

(英) Notch receptor-mediated signaling is involved in the developmental process and functional modulation of lymphocytes, as well as in mast cell differentiation. Here, we investigated whether Notch signaling is required for antipathogen host defense regulated by mast cells. Mast cells were rarely found in the small intestine of wild-type C57BL/6 mice but accumulated abnormally in the lamina propria of the small-intestinal mucosa of the Notch2-conditional knockout mice in naive status. When transplanted into mast cell-deficient W(sh)/W(sh) mice, Notch2-null bone marrow-derived mast cells were rarely found within the epithelial layer but abnormally localized to the lamina propria, whereas control bone marrow-derived mast cells were mainly found within the epithelial layer. After the infection of Notch2 knockout and control mice with L3 larvae of Strongyloides venezuelensis, the abundant number of mast cells was rapidly mobilized to the epithelial layer in the control mice. In contrast, mast cells were massively accumulated in the lamina propria of the small intestinal mucosa in Notch2-conditional knockout mice, accompanied by impaired eradication of Strongyloides venezuelensis. These findings indicate that cell-autonomous Notch2 signaling in mast cells is required for proper localization of intestinal mast cells and further imply a critical role of Notch signaling in the host-pathogen interface in the small intestine.

1. (英) Animals
2. (英) Basement Membrane
3. (英) Bone Marrow
4. (英) Bone Marrow Transplantation
5. (英) Cell Movement
6. (英) Cells, Cultured
7. (英) Female
8. (英) Integrases
9. (英) Intestinal Mucosa
10. (英) Intestine, Small
11. (英) Male
12. (英) Mast Cells
13. (英) Mice
14. (英) Mice, Inbred C57BL
15. (英) Mice, Knockout
16. (英) Mice, Transgenic
17. (英) Receptor, Notch2
18. (英) Strongyloides
19. (英) Strongyloidiasis

1. (英) Article.Affiliation: Department of Clinical and Experimental Hematology, University of Tsukuba, Tsukuba, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't