徳島大学 教育・研究者情報データベース(EDB)

1. 新井 英一

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2. (英) Awane Naomi

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3. 水野 昭

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4. (英) Fukaya Makiko

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5. (英) Sakuma Masae

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6. 原田 永勝

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7. (英) Kawaura Akihiko

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8. 山本 浩範

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9. 奥村 仙示

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10. 竹谷 豊([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])

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11. 土井 俊夫

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12. 武田 英二

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(英) Increasing early insulin secretion compensate adequately for hepatic insulin resistance in CCl4-induced cirrhosis rats.

(英) A number of recent publications have reported an increased frequency prevalence of glucose intolerance with hyperinsulinemia in liver cirrhosis. The aim of this work was to detect, in CCl(4)-induced liver cirrhosis rat, the presence and starting point of muscle and liver insulin resistance. Eighteen rats received intraperitoneal injection of 2 ml of soybean oil containing of CCl(4) twice a week for 20 weeks. We executed standard oral glucose tolerance and clamp study to evaluate systemic insulin resistance. Hepatic glucose uptake was much lower in CCl(4) group than that in control group, but peripheral glucose uptake was not decreased in this study. In contrast, early-phase insulin secretion was enhanced in CCl(4) rat using oral glucose load during clamp methods. These data suggested that increased early insulin secretion compensate adequately for hepatic insulin resistance in rats. However there was a report that peripheral glucose uptake was decreased in the case of human liver cirrhosis, which was formed in the course of time. In a chronic condition, this may be associated with reduced insulin content and developed systemic insulin resistance in liver cirrhosis. Then a long term observation study will be required to examine the presence of muscle insulin resistance in liver cirrhosis.

1. (英) Animals
2. (英) Body Weight
3. 四塩化炭素(carbon tetrachloride)
4. グルコース(glucose)
5. インスリン(insulin)
6. インスリン抵抗性(insulin resistance)
7. (英) Liver
8. (英) Liver Cirrhosis, Experimental
9. (英) Male
10. (英) Organ Size
11. (英) Rats
12. (英) Rats, Sprague-Dawley

1. (英) Article.Affiliation: Department of Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't