徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.総合科学教育部(2009年4月1日〜)

1. (英) Endo Yosuke / (日) 遠藤 陽介 / (読) えんどう ようすけ

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

2. (英) Han Zhehao / (日) 韓 哲浩 / (読) かん てっこう

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

3. (英) Kurochi Jun / (日) 黒地 潤 / (読) くろち じゅん

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

4. (英) Sakata Masahiro / (日) 坂田 真宏 / (読) さかた まさひろ

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

5. (英) Maetaka Akinori / (日) 前髙 明典 / (読) まえたか あきのり

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

6. (英) Yonezawa Takayasu / (日) 米澤 孝康 / (読) よねざわ たかやす

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

7. (英) Koizumi Kazuki / (日) 幸泉 和樹 / (読) こいずみ かずき

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

8. 小山 保夫

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Zinc-pyrithione exerts diverse actions on human leukemia K562 cells: A preliminary study on hormetic action

(英) Zinc-pyrithione is widely used as a topical agent. It may be likely that zinc-pyrithione possesses unique cytotoxic action because zinc exerts diverse actions on process of cell death. In this study, we examined the cytotoxicity of zinc-pyrithione on human leukemia K562 cells in order to examine the possibility of hormetic action. Zinc-pyrithione at concentrations ranging from 0.3 µM to 3 µM induced diverse actions on K562 cells. The agent at 0.3 and 1 µM significantly inhibited spontaneous occurrence of cell death during 72 h incubation while it was not the case for 3 µM. Significant decrease in population of shrunken cells was observed when the concentrations of zinc-pyrithione were 0.3 and 1 µM. Cell growth was significantly inhibited by 1 and 3 µM zinc-pyrithione, but not by 0.3 µM. Although the inhibition of cell growth by zinc-pyrithione was concentration-dependent, the inhibition of spontaneous cell death was observed only at lower concentrations (0.3 and 1 µM) of zinc-pyrithione. Results suggest that zinc-pyrithione possesses diverse actions, including hormetic action, on proliferative cells.

1. (英) Zinc-pyrithione
2. 細胞毒性(cytotoxicity)
3. (英) K562 cells