徳島大学 教育・研究者情報データベース(EDB)

1. (英) Kato Masatoshi / (日) 加藤 雅俊

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2. (英) Hazama Shoichi / (日) 硲 彰一

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3. (英) Sakamoto Kazuhiko / (日) 坂本 和彦

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4. (英) Yoshino Shigefumi / (日) 吉野 茂文

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5. 丹黒 章

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6. (英) Oka Masaaki / (日) 岡 正朗

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(英) [Significance of intracellular cytokines levels in peripheral lymphocytes for evaluation of surgical stress after hepatectomy in patients with hepatocellular carcinoma].

(日) 肝癌切除の手術侵襲評価におけるCD4陽性リンパ球内サイトカイン測定の意義

(英) It is difficult to evaluate surgical stress of patients with hepatocellular carcinoma (HCC). Cytokine production from the liver is decreased due to the liver dysfunction that is usually associated with HCCs. Therefore, we evaluated surgical stress after hepatectomy by measuring intracellular cytokines of lymphocytes in peripheral blood. We examined 22 patients with digestive cancers (8 with HCC, 10 with gastric cancer, and 4 with esophageal cancer). The concentrations of serum IL-6 levels 6 h after hepatectomy, gastrectomy, and esophagectomy were 268 +/- 84, 309 +/- 93, and 1,323 +/- 364 pg/ml, respectively. There was no significant difference between hepatectomy and gastrectomy, though based on clinical observations, it is estimated the surgical stress of hepatectomy was greater than that of gastrectomy. Conversely, the percentage of CD4+IL-6+ cells 6 h after surgery was 8.5 +/- 2.8, 3.3 +/- 0.6, and 7.8 +/- 3.4%, respectively. The percentage of CD4+IL-6+ cells after hepatectomy was significantly higher than that after gastrectomy. We estimated that the percentage of CD4+IL-6+ cells was an appropriate indicator of surgical stress on HCC, because the percentage of CD4+IL-6+ cells correlated well with the duration of surgery more than did the serum IL-6 levels. These results suggest that the percentage of CD4+IL-6+ cells may help in accurately evaluating surgical stress in patients with liver dysfunctions such as HCC.

1. (英) CD4-Positive T-Lymphocytes
2. (英) Carcinoma, Hepatocellular
3. 細胞質分裂(cytokinesis)
4. (英) Esophageal Neoplasms
5. (英) Hepatectomy
6. (英) Humans
7. (英) Interleukin-6
8. (英) Liver Neoplasms
9. (英) Lymphocytes
10. (英) Stomach Neoplasms

1. (英) Article.Affiliation: Yamaguchi University School of Medicine.

2. (英) Article.PublicationTypeList.PublicationType: English Abstract

3. (英) Article.PublicationTypeList.PublicationType: Journal Article