著作: [永井 宏和]/[髙丸 菜都美]/[大江 剛]/[内田 大亮]/[玉谷 哲也]/[藤澤 健司]/[岩本 誠司]/[宮本 洋二]/口腔扁平上皮癌に対するS-1を併用したDocetaxel超選択的動注化学療法の臨床効果に関する研究/[癌と化学療法]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 日本語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) [Evaluation of Combination Chemotherapy with Oral S-1 Administration Followed by Docetaxel by Superselective Intra-Arterial Infusion for Patients with Oral Squamous Cell Carcinomas.] (日) 口腔扁平上皮癌に対するS-1を併用したDocetaxel超選択的動注化学療法の臨床効果に関する研究 |
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副題 | 任意 | ||||
要約 | 任意 |
(英) The purpose of this study was to evaluate the effectiveness and adverse events of combination chemotherapy with oral S-1 administration following docetaxel(DOC)treatment by superselective intra-arterial infusion as neo-adjuvant chemotherapy (NAC)for patients with oral squamous cell carcinoma. Thirteen patients were enrolled in this study(9 men and 4 women, with a mean age of 61. 0 years). All patients were given S-1 65mg/m / 2 per day for 14 days, and DOC 40-50mg/m2 by intraarterial infusion was administered. The locoregional response evaluated 3 weeks after administration was 100%, including a 69. 2% complete response. According to Oboshi and Shimosato's classification, histological evaluation of surgical specimens revealed that 3 cases were Grade IIa, 4 cases Grade IIb, 1 case Grade IVa, and 4 cases Grade IVc. The severe side effects were neutropenia and cerebral infarction. The present study suggests that combination chemotherapy with S-1 and DOC by superselective intra-arterial infusion would be an effective and safe regimen in NAC for oral squamous cell carcinomas. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
癌と化学療法(癌と化学療法社)
(pISSN: 0385-0684)
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巻 | 必須 | 38 | |||
号 | 必須 | 5 | |||
頁 | 必須 | 777 781 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2011年 5月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | ||||
PMID | 任意 | 21566436 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | 2-s2.0-79960998915 | |||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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