徳島大学 教育・研究者情報データベース(EDB)

1. 島袋 充生

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2. (英) Shinzato Tatsushi

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3. (英) Higa Satoshi

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4. (英) Nagamine Fumio

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5. (英) Murakami Keiji

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6. (英) Takasu Nobuyuki

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(英) Impaired mechanical response to calcium of diabetic rat hearts: reversal by nifedipine treatment.

(英) Streptozotocin-induced diabetic and age-matched control rats were treated with 0.03% nifedipine-containing chow for 6 weeks, and mechanical response to Ca2+ was studied using isolated working hearts. At 14 weeks of age, 7 weeks after a streptozotocin injection, diabetic rats had a lower body weight and heart weight than controls, and an increase in heart weight-to-body weight ratio. Nifedipine treatment did not alter these parameters of controls, but decreased the heart weight and heart weight-to-body weight ratio of diabetic rats without affecting the body weight. In diabetic rats, systolic blood pressure was decreased compared to controls (124 +/- 5 vs. 137 +/- 6 mm Hg, p < 0.01), and reduced more by nifedipine treatment (111 +/- 4 mm Hg, p < 0.01). In control rats, LV developed pressure, LV +/- dP/dt, and cardiac work were unchanged regardless of the increment in preload at 1.25, 1.88, and 2.50 mM Ca2+. However, the responses of diabetic rats were decreased with an increment in preload at 2.5 mM Ca2+. Nifedipine treatment produced a partial recovery of all four parameters at 2.5 mM Ca2+ in diabetic rats. The myocardial Ca2+ content and sarcolemmal lipid peroxidation were similar in hearts from control and diabetic rats at all Ca2+ concentrations and nifedipine treatment did not affect these values. Results suggest that chronic nifedipine treatment improve the contractility of diabetic rat hearts under high Ca2+ conditions.

1. 分散分析(analysis of variance)
2. (英) Animals
3. (英) Blood Glucose
4. 血圧(blood pressure)
5. (英) Body Weight
6. カルシウム(calcium)
7. (英) Diabetes Mellitus, Experimental
8. 心臓(heart)
9. (英) Heart Rate
10. (英) Hemoglobin A, Glycosylated
11. インスリン(insulin)
12. 脂質過酸化(lipid peroxidation)
13. (英) Male
14. 心筋(myocardium)
15. (英) Nifedipine
16. (英) Organ Size
17. (英) Rats
18. (英) Rats, Sprague-Dawley

1. (英) Affiliation: Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa.

2. (英) PublicationType: Comparative Study

3. (英) PublicationType: In Vitro

4. (英) PublicationType: Journal Article