227556: Zhou Y T/Grayburn P/Karim A/[島袋充生]/Higa M/Baetens D/Orci L/Unger R H/Lipotoxic heart disease in obese rats: implications for human obesity./[Proceedings of the National Academy of Sciences of the United States of America]

著作: Zhou Y T/Grayburn P/Karim A/[島袋充生]/Higa M/Baetens D/Orci L/Unger R H/Lipotoxic heart disease in obese rats: implications for human obesity./[Proceedings of the National Academy of Sciences of the United States of America]

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EID: 227556
EOID: 895800
Map: 0
LastModified: 2018年3月30日(金) 17:07:36
Operator: 三木ちひろ
Avail: TRUE
Censor: 承認済
Owner: [副研究部長]/[徳島大学.大学院医歯薬学研究部]
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

必須

(英) Zhou Y T

役割任意

貢献度任意

学籍番号推奨
(英) Grayburn P

役割任意

貢献度任意

学籍番号推奨
(英) Karim A

役割任意

貢献度任意

学籍番号推奨
島袋充生

役割任意

貢献度任意

学籍番号推奨
(英) Higa M

役割任意

貢献度任意

学籍番号推奨
(英) Baetens D

役割任意

貢献度任意

学籍番号推奨
(英) Orci L

役割任意

貢献度任意

学籍番号推奨
(英) Unger R H

役割任意

貢献度任意

学籍番号推奨

題名

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(英) Lipotoxic heart disease in obese rats: implications for human obesity.

副題

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要約

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(英) To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was high because of underexpression of fatty acid oxidative enzymes and their transcription factor, peroxisome proliferator-activated receptor-alpha. Levels of ceramide, a mediator of apoptosis, were 2-3 times those of controls and inducible nitric oxide synthase levels were 4 times greater than normal. Myocardial DNA laddering, an index of apoptosis, reached 20 times the normal level. Troglitazone therapy lowered myocardial TG and ceramide and completely prevented DNA laddering and loss of cardiac function. In this paper, we conclude that cardiac dysfunction in obesity is caused by lipoapoptosis and is prevented by reducing cardiac lipids.

キーワード

推奨

(英) Age Factors
(英) Animals
アポトーシス(apoptosis)
(英) Blood Glucose
(英) Body Weight
(英) Chromans
(英) DNA Fragmentation
(英) Echocardiography
(英) Heart Diseases
(英) Humans
インスリン(insulin)
(英) Lipid Metabolism
(英) Male
(英) Microscopy, Electron
心筋(myocardium)
肥満症(obesity)
(英) Organ Size
(英) RNA, Messenger
(英) Rats
(英) Rats, Zucker
(英) Thiazoles
(英) Thiazolidinediones

発行所

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誌名

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Proceedings of the National Academy of Sciences of the United States of America([The National Academy of Sciences of the United States of America])

(pISSN: 0027-8424, eISSN: 1091-6490)

ISSN	任意	0027-8424 ISSN: 0027-8424 (pISSN: 0027-8424, eISSN: 1091-6490) Title: Proceedings of the National Academy of Sciences of the United States of America Title(ISO): Proc Natl Acad Sci U S A Publisher: National Academy of Sciences (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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1784 1789

都市

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年月日

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2000年 2月 15日

URL

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DOI

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10.1073/pnas.97.4.1784 (→Scopusで検索)

PMID

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10677535 (→Scopusで検索)

CRID

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WOS

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Scopus

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2-s2.0-0034652225

評価値

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被引用数

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指導教員

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備考

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(英) Article.Affiliation: Gifford Laboratories, Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.
(英) OtherID: PMC26513

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Zhou Y T/Grayburn P/Karim A/[島袋充生]/Higa M/Baetens D/Orci L/Unger R H/Lipotoxic heart disease in obese rats: implications for human obesity./[Proceedings of the National Academy of Sciences of the United States of America]

著作: Zhou Y T/Grayburn P/Karim A/[島袋 充生]/Higa M/Baetens D/Orci L/Unger R H/Lipotoxic heart disease in obese rats: implications for human obesity./[Proceedings of the National Academy of Sciences of the United States of America]

著作: Zhou Y T/Grayburn P/Karim A/[島袋充生]/Higa M/Baetens D/Orci L/Unger R H/Lipotoxic heart disease in obese rats: implications for human obesity./[Proceedings of the National Academy of Sciences of the United States of America]