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著作: Mitsui Fumihiko/Dobashi Yoh/[井本 逸勢]/Inazawa Johji/Kono Koji/Fujii Hideki/Ooi Akishi/Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomas./[Modern Pathology]

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EID
225978
EOID
1003069
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LastModified
2021年3月19日(金) 16:09:10
Operator
三木 ちひろ
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[副研究部長]/[徳島大学.大学院医歯薬学研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Mitsui Fumihiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Dobashi Yoh
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 井本 逸勢
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Inazawa Johji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kono Koji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Fujii Hideki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Ooi Akishi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomas.

副題 任意
要約 任意

(英) This study was conducted to assess the frequencies of protein overexpression and gene amplification of Myc and to identify the mechanisms of Myc gene amplification, especially with regards to its possible coamplification with ERBB2 or EGFR in gastric adenocarcinomas. By immunohistochemical analysis of a total of 300 formalin-fixed and paraffin-embedded gastric adenocarcinomas, the nuclear overexpression of MYC was found in 47 tumors (16%). A fluorescence in situ hybridization (FISH) analysis revealed that nine (19%) of the 47 tumors with protein overexpression had cancer cells with high levels of Myc amplification, whereas only seven (6%) of the 122 tumors without protein overexpression showed high-level Myc gene amplification. Such Myc amplification was significantly correlated with positive nuclear protein overexpression. The coamplification of ERBB2 or EGFR with Myc that was found in six and four cases, respectively, is believed to be non-incidental because those frequencies were significantly higher than the individual frequencies observed for the total examined cases (ERBB2: 7%; EGFR: 4%). The high levels of gene amplification of these three genes, as visualized by FISH, could be broadly classified into two typical types, namely, 'multiple scattered signals' and 'large clustered signals'. Using two-color FISH, the coexistence of coamplified Myc and ERBB2, or Myc and EGFR, within single nuclei in various combinations of amplification types and copy numbers, could be ascertained in all nine cases, including one in which the synchronous 'multiple scattered type' coamplification of Myc and ERBB2 was observed. In three tumors, coamplification of ERBB2 and EGFR was found; however, ERBB2- and EGFR-amplified cell populations were separate and mutually exclusive. We propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement.

キーワード 推奨
  1. (英) Adenocarcinoma
  2. (英) Cell Nucleus
  3. (英) Gene Dosage
  4. (英) Humans
  5. 免疫組織化学(immunohistochemistry)
  6. (英) In Situ Hybridization, Fluorescence
  7. (英) Lymph Nodes
  8. (英) Lymphatic Metastasis
  9. (英) Proto-Oncogene Proteins c-myc
  10. (英) Receptor, Epidermal Growth Factor
  11. (英) Receptor, erbB-2
  12. (英) Stomach Neoplasms
発行所 推奨
誌名 必須 Modern Pathology(United States and Canadian Academy of Pathology)
(pISSN: 0893-3952, eISSN: 1530-0285)
ISSN 任意 0893-3952
ISSN: 0893-3952 (pISSN: 0893-3952, eISSN: 1530-0285)
Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Title(ISO): Mod Pathol
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 20
必須 6
必須 622 631
都市 任意
年月日 必須 2007年 6月 初日
URL 任意
DOI 任意 10.1038/modpathol.3800777    (→Scopusで検索)
PMID 任意 17431415    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-34249021159
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan.

  2. (英) PublicationType: Journal Article

  3. (英) PublicationType: Research Support, Non-U.S. Gov't