徳島大学 教育・研究者情報データベース(EDB)

1. (英) Doi Naoya

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2. (英) Fujiwara Sachi

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3. 足立 昭夫

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4. 野間口 雅子([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.微生物病原学])

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(英) Growth ability in various macaque cell lines of HIV-1 with simian cell-tropism.

(英) We have recently constructed a series of novel human immunodeficiency viruses (HIV-1s) that are tropic for a macaque cell line (mt; macaque cell-tropic) to generate and establish a primate experimental system for HIV-1/AIDS study. In order to determine biological properties of these viruses effectively, several other macaque cell lines with distinct characteristics that can be routinely and easily used, instead of primary cells, for infection experiments are required. In this study, we have examined four macaque cell lines for their surface expression of virus receptor molecules and for their genotype of a major anti-viral capsid gene. Furthermore, we monitored the susceptibility of the cell lines to a standard simian immunodeficiency virus (SIV) clone and three representative basic mt HIV-1 clones. Results obtained here have clearly indicated that these cell lines are exquisitely useful to characterize various SIVs and more importantly, mt HIV-1s.

1. (英) Alleles
2. (英) Animals
3. (英) Cell Line
4. 遺伝子発現(gene expression)
5. (英) Genome, Viral
6. (英) HIV-1
7. (英) Humans
8. (英) Macaca
9. (英) Proteins
10. (英) Receptors, HIV
11. (英) Simian immunodeficiency virus
12. (英) Species Specificity
13. (英) Viral Tropism

1. (英) Article.Affiliation: Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't