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著作: Min Li-Juan/Cui Tai-Xing/Yahata Yoko/Yamasaki Kenshi/Liu Hong-Wei/Chen Rui/Li Jian-Mei/Okumura Midori/Jinno Toyohisa/Wu Lan/Iwai Masaru/Nahmias Clara/Hashimoto Koji/Horiuchi Masatsugu/Regulation of collagen synthesis in mouse skin fibroblasts by distinct angiotensin II receptor subtypes./[Endocrinology]

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EID
221440
EOID
654597
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LastModified
2012年8月29日(水) 12:48:54
Operator
大家 隆弘
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志内 哲也
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Min Li-Juan
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Cui Tai-Xing
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yahata Yoko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Yamasaki Kenshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Liu Hong-Wei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Chen Rui
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Li Jian-Mei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Okumura Midori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Jinno Toyohisa
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. (英) Wu Lan
    役割 任意
    貢献度 任意
    学籍番号 推奨
  11. (英) Iwai Masaru
    役割 任意
    貢献度 任意
    学籍番号 推奨
  12. (英) Nahmias Clara
    役割 任意
    貢献度 任意
    学籍番号 推奨
  13. (英) Hashimoto Koji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  14. (英) Horiuchi Masatsugu
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Regulation of collagen synthesis in mouse skin fibroblasts by distinct angiotensin II receptor subtypes.

副題 任意
要約 任意

(英) We examined the possibility of whether angiotensin (Ang) II type 1 (AT1) and type 2 (AT2) receptor stimulation differentially regulates collagen production in mouse skin fibroblasts. Both AT1 and AT2 receptors were expressed in neonatal skin fibroblasts prepared from wild-type mice to a similar degree, and the AT1a receptor was exclusively expressed as opposed to the AT1b receptor. In wild-type fibroblasts, Ang II increased collagen synthesis accompanied by an increase in expression of tissue inhibitor of metalloproteinase (TIMP)-1, and these increases were inhibited by valsartan, an AT1 receptor blocker, but augmented by PD123319, an AT2 receptor antagonist. Ang II decreased basal and IGF-I-induced collagen production and inhibited TIMP-1 expression in neonatal skin fibroblasts prepared from AT1a knockout (KO) mice. These Ang II-mediated inhibitory effects on collagen production and TIMP-1 expression observed in AT1a KO fibroblasts were attenuated by the addition of PD123319 or a tyrosine phosphatase inhibitor, sodium orthovanadate, but not affected by a serine/threonine phosphatase inhibitor, okadaic acid. Moreover, we demonstrated that transfection of a catalytically inactive, dominant negative SHP-1 (Src homology 2-containing protein-tyrosine phosphatase-1) mutant inhibited the Ang II-mediated inhibitory effect on both collagen synthesis and TIMP-1 expression in AT1a KO fibroblasts. These results suggest that AT1a receptor stimulation increases collagen production in skin fibroblasts at least in part due to the inhibition of collagen degradation via the increase in TIMP-1 expression, whereas AT2 receptor stimulation exerts inhibitory effects on TIMP-1 expression, which is mediated at least partially by the activation of SHP-1, thereby possibly inhibiting collagen production.

キーワード 推奨
  1. (英) Animals, Newborn
  2. (英) Cells, Cultured
  3. (英) Collagen
  4. (英) Enzyme Inhibitors
  5. (英) Fibroblasts
  6. (英) Gene Expression
  7. (英) Intracellular Signaling Peptides and Proteins
  8. (英) Male
  9. (英) Mice
  10. (英) Mice, Knockout
  11. (英) Okadaic Acid
  12. (英) Protein Phosphatase 1
  13. (英) Protein Tyrosine Phosphatase, Non-Receptor Type 1
  14. (英) Protein Tyrosine Phosphatase, Non-Receptor Type 6
  15. (英) Protein Tyrosine Phosphatases
  16. (英) Receptor, Angiotensin, Type 1
  17. (英) Receptor, Angiotensin, Type 2
  18. (英) Skin
  19. (英) Tissue Inhibitor of Metalloproteinase-1
  20. (英) Vanadates
発行所 推奨
誌名 必須 Endocrinology([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)
ISSN 任意 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 145
必須 1
必須 253 260
都市 任意
年月日 必須 2003年 10月 9日
URL 任意
DOI 任意 10.1210/en.2003-0673    (→Scopusで検索)
PMID 任意 14551224    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Medical Biochemistry, Ehime University Medical School, Onsen-gun, Ehime 791-0295, Japan.

  2. (英) PublicationType: Journal Article

  3. (英) PublicationType: Research Support, Non-U.S. Gov't