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著作: Miura Shinji/Kawanaka Kentaro/Kai Yuko/Tamura Mayumi/Goto Masahide/[志内 哲也]/Minokoshi Yasuhiko/Ezaki Osamu/An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation./[Endocrinology]

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EID
221429
EOID
654588
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LastModified
2012年8月29日(水) 12:47:42
Operator
大家 隆弘
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志内 哲也
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Miura Shinji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kawanaka Kentaro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kai Yuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Tamura Mayumi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Goto Masahide
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 志内 哲也([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Minokoshi Yasuhiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Ezaki Osamu
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation.

副題 任意
要約 任意

(英) A single bout of exercise increases expression of peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha mRNA, which may promote mitochondrial biogenesis in skeletal muscle. In brown adipose tissue, cold exposure up-regulates PGC-1alpha expression via adrenergic receptor (AR) activation. Because exercise also activates the sympathetic nervous system, we examined whether exercise-induced increase in PGC-1alpha mRNA expression in skeletal muscle was mediated via AR activation. In C57BL/6J mice, injection of the beta2-AR agonist clenbuterol, but not alpha-, beta1-, or beta3-AR agonists, increased PGC-1alpha mRNA expression more than 30-fold in skeletal muscle. The clenbuterol-induced increase in PGC-1alpha mRNA expression in mice was inhibited by pretreatment with the beta-AR antagonist propranolol. In ex vivo experiments, direct exposure of rat epitrochlearis to beta2-AR agonist, but not alpha-, beta1-, and beta3-AR agonist, led to an increase in levels of PGC-1alpha mRNA. Injection of beta2-AR agonist did not increase PGC-1alpha mRNA expression in beta1-, beta2-, and beta3-AR knockout mice (beta-less mice). PGC-1alpha mRNA in gastrocnemius was increased 3.5-fold in response to running on a treadmill for 45 min. The exercise-induced increase in PGC-1alpha mRNA was inhibited by approximately 70% by propranolol or the beta2-AR-specific inhibitor ICI 118,551. The exercise-induced increase in PGC-1alpha mRNA in beta-less mice was also 36% lower than that in wild-type mice. These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise.

キーワード 推奨
  1. (英) Adrenergic beta-1 Receptor Agonists
  2. (英) Adrenergic beta-2 Receptor Agonists
  3. (英) Adrenergic beta-3 Receptor Agonists
  4. (英) Adrenergic beta-Agonists
  5. (英) Animals
  6. (英) Blotting, Northern
  7. (英) Clenbuterol
  8. (英) Dioxoles
  9. (英) Dobutamine
  10. (英) Gene Expression Regulation
  11. (英) Mice
  12. (英) Mice, Inbred C57BL
  13. (英) Mice, Knockout
  14. (英) Muscle, Skeletal
  15. (英) Phenylephrine
  16. (英) Physical Conditioning, Animal
  17. (英) Propranolol
  18. (英) RNA, Messenger
  19. (英) Receptors, Adrenergic, alpha
  20. (英) Receptors, Adrenergic, beta
  21. (英) Receptors, Adrenergic, beta-1
  22. (英) Receptors, Adrenergic, beta-2
  23. (英) Receptors, Adrenergic, beta-3
  24. (英) Reverse Transcriptase Polymerase Chain Reaction
  25. (英) Trans-Activators
発行所 推奨
誌名 必須 Endocrinology([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)
ISSN 任意 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 148
必須 7
必須 3441 3448
都市 任意
年月日 必須 2007年 4月 19日
URL 任意
DOI 任意 10.1210/en.2006-1646    (→Scopusで検索)
PMID 任意 17446185    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Nutritional Science Program, National Institute of Health and Nutrition, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8636, Japan. shinjim@nih.go.jp

  2. (英) PublicationType: Journal Article

  3. (英) PublicationType: Research Support, Non-U.S. Gov't