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著作: [安井 武史]/Tohno Yoshiyuki/[荒木 勉]/Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetry/[Journal of Biomedical Optics]

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EID
220633
EOID
693239
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LastModified
2013年7月2日(火) 16:00:27
Operator
大家 隆弘
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安井 武史
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
  1. SPIE The International Society for Optical Engineering
著者 必須
  1. 安井 武史([徳島大学.ポストLEDフォトニクス研究所]/[徳島大学.理工学部.理工学科.機械科学コース.生産工学講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Tohno Yoshiyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 荒木 勉([大阪大学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetry

副題 任意
要約 任意

(英) We have proposed an optical probe that can be used to characterize the orientation of collagen fibers in human dermis. A specific probing ability for collagen results from the use of second-harmonic-generation (SHG) light induced by collagen molecules in the tissue. Based on the concept of collagen SHG light, a reflection-type polarization measurement system (named SHG polarimetry) with a probe light spot of 15 microm in diameter has been constructed, and the human reticular dermis has been measured using this system. Resultant data exhibit that the reticular dermis possesses approximately uniaxial orientation of the collagen fibers. Furthermore, we demonstrated a nondestructive measurement of the collagen orientation in the papillary dermis across an epidermis layer. For distribution measurement of the collagen fiber orientation in the reticular dermis, we have extended the SHG polarimetry to one- (1-D) and two-dimensional (2-D) measurement. By the macroscopic 2-D SHG polarimetry, we have observed that the orientation angle and organization degree of collagen fibers vary widely depending on the discrete probing positions in the reticular dermis. Furthermore, microscopic 1-D SHG polarimetry indicated a swell of the orientation angle and a large variance of the organization degree in the collagen fibers in the microscopic region. These results imply that the reticular dermis posses a tangled structure of collagen fibers, which is highly consistent with the result of the anatomical examination of the skin. The proposed method will be a powerful tool for monitoring the microscopic distribution of the collagen fiber orientation in the human dermis.

キーワード 推奨
  1. (英) Achilles Tendon
  2. (英) Animals
  3. (英) Cattle
  4. (英) Cells, Cultured
  5. (英) Collagen
  6. (英) Dermis
  7. (英) Humans
  8. (英) Microscopy, Polarization
  9. (英) Models, Theoretical
  10. (英) Tissue Distribution
発行所 推奨 SPIE The International Society for Optical Engineering
誌名 必須 Journal of Biomedical Optics(Society of Photo-optical Instrumentation Engineers/International Biomedical Optics Society)
(pISSN: 1083-3668, eISSN: 1560-2281)
ISSN 任意 1083-3668
ISSN: 1083-3668 (pISSN: 1083-3668, eISSN: 1560-2281)
Title: Journal of biomedical optics
Title(ISO): J Biomed Opt
Publisher: S P I E - International Society for Optical Engineering
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 9
必須 2
必須 259 264
都市 任意
年月日 必須 2004年 3月 初日
URL 任意
DOI 任意 10.1117/1.1644116    (→Scopusで検索)
PMID 任意 15065889    (→Scopusで検索)
NAID 任意
WOS 任意 000220702200004
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Osaka University, Graduate School of Engineering Science, Toyonaka, Osaka, 560-8531 Japan. t-yasui@me.es.osaka-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) MedlineDate: 2004 Mar-Apr