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著作: [柏原 考爾]/Kawada Toru/Uemura Kazunori/Sugimachi Masaru/Sunagawa Kenji/Adaptive predictive control of arterial blood pressure based on a neural network during acute hypotension./[Annals of Biomedical Engineering]

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EID
220009
EOID
691281
Map
0
LastModified
2013年6月17日(月) 16:09:56
Operator
大家 隆弘
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TRUE
Censor
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Owner
柏原 考爾
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 柏原 考爾
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kawada Toru
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Uemura Kazunori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Sugimachi Masaru
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Sunagawa Kenji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Adaptive predictive control of arterial blood pressure based on a neural network during acute hypotension.

副題 任意
要約 任意

(英) In acute hypotension, an automated drug infusion system to control mean arterial blood pressure (MAP) has not been previously studied, though many investigations have examined the use of vasodilating drugs to control MAP in postoperative hypertension. Therefore, we examined an automated control of MAP during acute hypotension using a neural network (NN) approach. A proportional-integral-derivative (PID) control, an adaptive predictive control using a NN (APC(NN)), a combined control of APC(NN) and PID (APC(NN-PID)), a fuzzy control, and a model predictive control were tested in computer simulation based on the MAP response to norepinephrine (NE) of 25 microg ml(-1). In six anesthetized rabbits, using the NE of 25 microg ml(-1), the PID control, APC(NN), and APC(NN-PID) prevented severe hypotension compared to an uncontrolled condition. Under PID control, four of the six animals showed MAP oscillation. Using NE of 50 microg ml(-1), the rabbits recovered from acute hypotension for all systems tested but showed sustained MAP oscillation during PID control. In conclusion, utilization of a NN for adaptive predictive control systems could facilitate the development of an automated drug infusion apparatus because it provides robust control even when acute or large perturbations and inter-individual differences in the sensitivity to therapeutic agents occur.

キーワード 推奨
  1. (英) Acute Disease
  2. (英) Adaptation, Physiological
  3. (英) Algorithms
  4. (英) Animals
  5. (英) Blood Pressure
  6. (英) Computer Simulation
  7. (英) Dose-Response Relationship, Drug
  8. (英) Drug Therapy, Computer-Assisted
  9. (英) Feedback
  10. (英) Hypotension
  11. (英) Infusion Pumps
  12. (英) Infusions, Intra-Arterial
  13. (英) Models, Cardiovascular
  14. (英) Neural Networks (Computer)
  15. (英) Norepinephrine
  16. (英) Rabbits
  17. (英) Treatment Outcome
  18. (英) Vasodilator Agents
発行所 推奨
誌名 必須 Annals of Biomedical Engineering(Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)
ISSN 任意 0090-6964
ISSN: 0090-6964 (pISSN: 0090-6964, eISSN: 1573-9686)
Title: Annals of biomedical engineering
Title(ISO): Ann Biomed Eng
Supplier: Kluwer Online
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 32
必須 10
必須 1365 1383
都市 任意
年月日 必須 2004年 10月 初日
URL 任意 http://ci.nii.ac.jp/naid/30020243567/
DOI 任意 10.1114/B:ABME.0000042225.19806.34    (→Scopusで検索)
PMID 任意 15535055    (→Scopusで検索)
NAID 任意 30020243567
WOS 任意 000223983400005
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan. kasihara@ri.ncvc.go.jp

  2. (英) Article.PublicationTypeList.PublicationType: Evaluation Studies

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  5. (英) Article.PublicationTypeList.PublicationType: Validation Studies