徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.医学部

1. 銭 志栄

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2. (英) Li Chiun Chei

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3. (英) Yamasaki Hiroyuki

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4. 水澤 典子([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])

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5. 吉本 勝彦

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6. (英) Yamada Shozo

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7. (英) Tashiro Takashi

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8. 堀口 英久

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9. 若槻 真吾([徳島大学.医学部.医学科.器官病態修復医学講座.分子病理学分野])

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10. 廣川 満良

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11. 佐野 壽昭

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(英) Role of E-cadherin, alpha-, beta-, and gamma-catenins, and p120 (cell adhesion molecules) in prolactinoma behavior.

(英) E-cadherin/catenin complex regulates cellular adhesion and motility and is believed to function as an invasion suppressor system. In a number of cancers, abnormal and reduced expression of E-cadherin/catenin complex is associated with tumor invasion and metastasis. Prolactinomas show frequent invasion on the surrounding structures, despite their histologically benign nature. Furthermore, gender-based differences in endocrine and surgical findings are found in patients with prolactinoma. To understand biological factors governing prolactinoma behavior, this study analyzed the expression of E-cadherin; alpha-, beta-, and gamma-catenins; p120; and cell proliferation marker MIB-1 labeling index in 13 invasive tumors (9 in men, 4 in women), 26 noninvasive tumors (4 in men, 22 in women), and 8 normal anterior pituitaries by immunohistochemistry. Immunostaining of E-cadherin; alpha-, beta-, and gamma-catenins; and p120 showed a membranous pattern of reactivity and generally stronger in normal pituitaries than in prolactinomas. Expression of E-cadherin and beta-catenin was significantly lower in invasive than in noninvasive prolactinomas (P <.002 and P <.005, respectively), and reduced expression of E-cadherin and beta-catenin was more frequent in invasive than in noninvasive prolactinomas (P <.001 and P <.05, respectively); in contrast, gamma-catenin expression showed higher in invasive than in noninvasive prolactinomas (P <.05). Expression of E-cadherin was significantly lower in macroprolactinomas than in microprolactinomas (P <.01), and decreased expression of E-cadherin and beta-catenin predicted high MIB-1 expression (P <.05). Moreover, the expression of E-cadherin and beta-catenin was significantly lower in macroprolactinomas in men than in those in women (P <.01 and P <.02, respectively). No statistical correlations were observed between expression of alpha-catenin, p120, and clinicopathologic features. In conclusion, the reduction of E-cadherin and beta-catenin expression was related to invasiveness and proliferative status of prolactinomas and correlated with the more aggressive behavior of prolactinomas in men compared with in women.

1. (英) Adolescent
2. (英) Adult
3. (英) Aged
4. (英) Cadherins
5. (英) Cell Adhesion Molecules
6. (英) Cytoskeletal Proteins
7. (英) Desmoplakins
8. (英) Female
9. (英) Humans
10. 免疫組織化学(immunohistochemistry)
11. (英) Ki-67 Antigen
12. (英) Male
13. (英) Middle Aged
14. (英) Phosphoproteins
15. (英) Pituitary Neoplasms
16. (英) Prolactinoma
17. (英) Trans-Activators
18. (英) alpha Catenin
19. (英) beta Catenin
20. (英) gamma Catenin

1. (英) Affiliation: Department of Pathology, School of Medicine, Tokushima University, Tokushima, Japan.

2. (英) PublicationType: Journal Article