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著作: [佐野 壽昭]/Mader Rene/Asa Sylvia L/[銭 志栄]/Hino Akiko/Yamada Shozo/"Honeycomb Golgi" in pituitary adenomas: not a marker of gonadotroph adenomas./[Endocrine Pathology]

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212969
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696213
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2013年7月24日(水) 20:43:56
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大家 隆弘
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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 佐野 壽昭
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Mader Rene
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Asa Sylvia L
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 銭 志栄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Hino Akiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Yamada Shozo
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) "Honeycomb Golgi" in pituitary adenomas: not a marker of gonadotroph adenomas.

副題 任意
要約 任意

(英) The vacuolar change in Golgi complexes known as "honeycomb Golgi" has been described as the ultrastructural hallmark of a specific tumor that has been called the "female gonadotroph" adenoma of the human pituitary. Recently, a few adenomas presenting with Cushing's disease have been reported to exhibit this feature. To clarify the significance of a "honeycomb Golgi" in the classification of pituitary adenomas, we studied clinically nonfunctioning adenomas with or without "honeycomb Golgi" using immunohistochemistry for adenohypophysial hormones and RT-PCR for the cell-specific transcription factors Tpit that identifies corticotrophs and SF-1 that identifies gonadotrophs. All adenomas were from women. Among 20 adenomas with complete "honeycomb Golgi" change, gonadotrophin subunits were totally immunonegative, but ACTH was positive in a few cells of 12 adenomas. Among eight adenomas with partial vacuolar change of the Golgi complex, five were positive for gonadotrophins and two were positive for ACTH. A subgroup of these lesions were examined by RT-PCR and among eight adenomas with typical "honeycomb Golgi" one case expressed both Tpit and SF-1, probably due to contamination with normal pituitary and another expressed neither Tpit nor SF-1. Of the remaining six cases, Tpit was expressed in two cases and SF-1 in four. These findings indicate that "honeycomb Golgi" change can been seen in corticotroph adenomas as well as gonadotroph adenomas. The reason why this vacuolar change occurs only in females remains to be clarified.

キーワード 推奨
  1. (英) Adenoma
  2. (英) Adrenocorticotropic Hormone
  3. (英) Adult
  4. (英) Aged
  5. (英) DNA-Binding Proteins
  6. (英) Female
  7. (英) Fushi Tarazu Transcription Factors
  8. (英) Golgi Apparatus
  9. (英) Gonadotropins, Pituitary
  10. (英) Homeodomain Proteins
  11. (英) Humans
  12. 免疫組織化学(immunohistochemistry)
  13. (英) Microscopy, Electron
  14. (英) Middle Aged
  15. (英) Pituitary Hormones, Anterior
  16. (英) Pituitary Neoplasms
  17. (英) Reverse Transcriptase Polymerase Chain Reaction
  18. (英) T-Box Domain Proteins
  19. (英) Transcription Factors
  20. (英) Vacuoles
発行所 推奨
誌名 必須 Endocrine Pathology(Endocrine Pathology Society)
(pISSN: 1046-3976, eISSN: 1559-0097)
ISSN 任意 1046-3976
ISSN: 1046-3976 (pISSN: 1046-3976, eISSN: 1559-0097)
Title: Endocrine pathology
Title(ISO): Endocr Pathol
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 14
必須 4
必須 363 368
都市 任意
年月日 必須 2003年 12月 10日
URL 任意
DOI 任意 10.1385/EP:14:4:363    (→Scopusで検索)
PMID 任意 14739492    (→Scopusで検索)
NAID 任意
WOS 任意 000188887200007
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Pathology, University of Tokushima School of Medicine, Tokushima, Japan. sano@basic.med.tokushima-u.ac.jp

  2. (英) PublicationType: Journal Article