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著作: [銭 志栄]/[佐野 壽昭]/Asa Sylvia L/Yamada Shozo/[堀口 英久]/Tashiro Takashi/Li Chiun Chei/[廣川 満良]/Kovacs Kalman/Ezzat Shereen/Cytoplasmic expression of fibroblast growth factor receptor-4 in human pituitary adenomas: relation to tumor type, size, proliferation, and invasiveness./[The Journal of Clinical Endocrinology and Metabolism]

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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 銭 志栄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 佐野 壽昭
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Asa Sylvia L
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Yamada Shozo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 堀口 英久
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Tashiro Takashi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Li Chiun Chei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 廣川 満良
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Kovacs Kalman
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. (英) Ezzat Shereen
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Cytoplasmic expression of fibroblast growth factor receptor-4 in human pituitary adenomas: relation to tumor type, size, proliferation, and invasiveness.

副題 任意
要約 任意

(英) The pathogenesis of pituitary adenomas remains unknown. A pituitary tumor-derived (ptd) isoform of fibroblast growth factor receptor-4 (ptd-FGFR4) has been implicated in the neoplastic process. To further understand the expression of FGFR4 in sporadic human pituitary adenomas, we studied 137 pituitary adenomas of various types (102 adenomas from Japanese patients and 35 adenomas from Canadian patients) and 10 nontumorous pituitaries using a polyclonal antiserum that recognizes the C terminus of FGFR4 and analyzed possible relationships among expression of FGFR4, patient nationality, tumor type, size, invasion, and the labeling index of the proliferation marker Ki-67 using the MIB-1 antibody. Cytoplasmic expression of FGFR4 protein was observed in 57.8% of Japanese cases and 62.8% of Canadian cases. FGFR4 reactivity was absent in all 10 normal adenohypophysial tissues examined. FGFR4 expression in pituitary adenomas was restricted mainly to the cytoplasm, a pattern similar to that seen in rat pituitary cells transfected with human ptd-FGFR4 but different from that of cells transfected with wild-type FGFR4, which displayed membrane localization of staining. Protein from primary human adenomas migrated as a 65-kDa species consistent with the predicted size of ptd-FGFR4. FGFR4 protein expression was frequently found in adenomas containing GH, ACTH, or FSH/LH and was also found in null cell adenomas, but reactivity was relatively rare in prolactin-containing adenomas in both Japanese and Canadian groups. The expression of FGFR4 protein was stronger in macroadenomas than in microadenomas (P = 0.02) and high levels of FGFR4 expression (moderate or greater density staining) were more frequently observed in macroadenomas than in microadenomas (P < 0.05). High levels of FGFR4 expression also correlated significantly with the proliferation marker Ki-67 (P = 0.002) and tended (but not significantly) to be found in invasive tumors. These data are consistent with a role for ptd-FGFR4 in pituitary tumorigenesis in a majority of human pituitary adenomas. Moreover, detection of FGFR4 cytoplasmic staining may provide an ancillary diagnostic tool in the diagnosis of pituitary adenoma, particularly in equivocal cases.

キーワード 推奨
  1. (英) Adenoma
  2. (英) Animals
  3. 細胞分裂(cell division)
  4. (英) Cell Line
  5. (英) Cytoplasm
  6. (英) Female
  7. (英) Humans
  8. 免疫組織化学(immunohistochemistry)
  9. (英) Ki-67 Antigen
  10. (英) Male
  11. (英) Neoplasm Invasiveness
  12. (英) Pituitary Neoplasms
  13. (英) Rats
  14. (英) Receptor, Fibroblast Growth Factor, Type 4
  15. (英) Receptors, Fibroblast Growth Factor
  16. (英) Transfection
発行所 推奨
誌名 必須 The Journal of Clinical Endocrinology and Metabolism([The Endocrine Society])
(pISSN: 0021-972X, eISSN: 1945-7197)
ISSN 任意 0021-972X
ISSN: 0021-972X (pISSN: 0021-972X, eISSN: 1945-7197)
Title: The Journal of clinical endocrinology and metabolism
Title(ISO): J Clin Endocrinol Metab
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 89
必須 4
必須 1904 1911
都市 任意
年月日 必須 2004年 4月 2日
URL 任意
DOI 任意 10.1210/jc.2003-031489    (→Scopusで検索)
PMID 任意 15070963    (→Scopusで検索)
NAID 任意
WOS 任意 000220714500059
Scopus 任意 2-s2.0-11144355395
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Pathology, University of Tokushima School of Medicine, Tokushima, Japan.

  2. (英) PublicationType: Journal Article