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著作: [廣川 満良]/Kuma Seiji/Miyauchi Akira/Qian Zhi Ring/Nakasono Masahiko/[佐野 壽昭]/Kakudo Kennichi/Morules in cribriform-morular variant of papillary thyroid carcinoma: Immunohistochemical characteristics and distinction from squamous metaplasia./[APMIS]

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EID
212967
EOID
674314
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LastModified
2013年1月7日(月) 09:46:47
Operator
松井 栄里
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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 廣川 満良
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kuma Seiji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Miyauchi Akira
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Qian Zhi Ring
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Nakasono Masahiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 佐野 壽昭
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Kakudo Kennichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Morules in cribriform-morular variant of papillary thyroid carcinoma: Immunohistochemical characteristics and distinction from squamous metaplasia.

副題 任意
要約 任意

(英) Morules are a diagnostic clue to the cribriform-morular variant (C-MV) of papillary thyroid carcinoma, and are superficially similar to squamous metaplasia. In order to clarify the histogenesis of morules and differentiate them from squamous metaplasia, we immunohistochemically compared the morules in five cases of C-MV with squamous metaplasia in six cases of diffuse sclerosing variant (DSV) of papillary thyroid carcinoma. The squamous metaplastic cells were immunopositive for low- and high-molecular-weight cytokeratin, whereas the morular cells were negative or focally positive. Vimentin-positive cells were observed focally in the morules and squamous metaplasia, except for one case of CMV that showed intense positivity. The morular cells showed weak cytoplasmic positivity for beta-catenin, and the cell membrane was not highlighted. Some nuclei of the morular cells were also positive for this antibody. Beta-catenin was intensively positive along the cell membrane of the metaplastic cells, and did not react against the nuclei or cytoplasm. Bcl-2 was positive in the morular cells, but negative in the metaplastic cells. S-100 protein-positive dendritic cells were observed in the metaplastic nests, but not in the morules. We argue that morules appear in connection with nuclear and cytoplasmic aberrant localization of beta-catenin, and are not an early form of squamous metaplasia.

キーワード 推奨
  1. (英) Adolescent
  2. (英) Adult
  3. (英) Carcinoma, Papillary
  4. (英) Carcinoma, Squamous Cell
  5. (英) Diagnosis, Differential
  6. (英) Female
  7. (英) Humans
  8. 免疫組織化学(immunohistochemistry)
  9. (英) Male
  10. (英) Neoplasm Proteins
  11. (英) Thyroid Neoplasms
発行所 推奨
誌名 必須 APMIS(Heymans Institute of Pharmacology)
(pISSN: 0903-4641, eISSN: 1600-0463)
ISSN 任意 0903-4641
ISSN: 0903-4641 (pISSN: 0903-4641, eISSN: 1600-0463)
Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Title(ISO): APMIS
Supplier: Scandinavian Societies for Medical Microbiology and Pathology
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 112
必須 4-5
必須 275 282
都市 任意
年月日 必須 2004年 4月 5日
URL 任意
DOI 任意 10.1111/j.1600-0463.2004.apm11204-0508.x    (→Scopusで検索)
PMID 任意 15233643    (→Scopusで検索)
NAID 任意
WOS 任意 000222916700008
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Pathology, University of Tokushima School of Medicine, Kuramoto-cho, Japan. hirokawa@basic.med.tokushima-u.ac.jp

  2. (英) PublicationType: Journal Article