徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Vedhachalam Charulatha/Duong T Phu/Nickel Margaret/Nguyen David/Dhanasekaran Padmaja/[斎藤 博幸]/Rothblat H George/Lund-Katz Sissel/Phillips C Michael/Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles./[The Journal of Biological Chemistry]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
212813
EOID
851622
Map
0
LastModified
2017年3月29日(水) 15:14:58
Operator
三木 ちひろ
Avail
TRUE
Censor
0
Owner
[副研究部長]/[徳島大学.大学院医歯薬学研究部]
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Vedhachalam Charulatha
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Duong T Phu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Nickel Margaret
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Nguyen David
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Dhanasekaran Padmaja
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 斎藤 博幸
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Rothblat H George
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Lund-Katz Sissel
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Phillips C Michael
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles.

副題 任意
要約 任意

(英) The ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the biogenesis of high density lipoprotein (HDL) particles and in mediating cellular cholesterol efflux. The mechanism by which ABCA1 achieves these effects is not established, despite extensive investigation. Here, we present a model that explains the essential features, especially the effects of ABCA1 activity in inducing apolipoprotein (apo) A-I binding to cells and the compositions of the discoidal HDL particles that are produced. The apo A-I/ABCA1 reaction scheme involves three steps. First, there is binding of a small regulatory pool of apo A-I to ABCA1, thereby enhancing net phospholipid translocation to the plasma membrane exofacial leaflet; this leads to unequal lateral packing densities in the two leaflets of the phospholipid bilayer. Second, the resultant membrane strain is relieved by bending and by creation of exovesiculated lipid domains. The formation of highly curved membrane surface promotes high affinity binding of apo A-I to these domains. Third, this pool of bound apo A-I spontaneously solubilizes the exovesiculated domain to create discoidal nascent HDL particles. These particles contain two, three, or four molecules of apo A-I and a complement of membrane phospholipid classes together with some cholesterol. A key feature of this mechanism is that membrane bending induced by ABCA1 lipid translocase activity creates the conditions required for nascent HDL assembly by apo A-I. Overall, this mechanism is consistent with the known properties of ABCA1 and apo A-I and reconciles many of the apparently discrepant findings in the literature.

キーワード 推奨
  1. (英) ATP-Binding Cassette Transporters
  2. アデノシン三リン酸(adenosine triphosphate)
  3. (英) Animals
  4. (英) Apolipoprotein A-I
  5. (英) Binding Sites
  6. (英) Cell Line
  7. (英) Cell Membrane
  8. (英) Dose-Response Relationship, Drug
  9. 免疫組織化学(immunohistochemistry)
  10. (英) Lipids
  11. (英) Lipoproteins, HDL
  12. (英) Macrophages
  13. (英) Mice
  14. (英) Microscopy, Electron
  15. (英) Models, Biological
発行所 推奨
誌名 必須 The Journal of Biological Chemistry([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)
ISSN 任意 0021-9258
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 282
必須 34
必須 25123 25130
都市 任意
年月日 必須 2007年 6月 29日
URL 任意
DOI 任意 10.1074/jbc.M704590200    (→Scopusで検索)
PMID 任意 17604270    (→Scopusで検索)
NAID 任意
WOS 任意 000248933000067
Scopus 任意 2-s2.0-34548364160
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

  2. (英) PublicationType: Journal Article

  3. (英) PublicationType: Research Support, N.I.H., Extramural