徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Lawson Mark A/Tsutsumi Rie/Zhang Hao/Talukdar Indrani/Butler Brian K/Santos Sharon J/Mellon Pamela L/Webster Nicholas J G/Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2./[Molecular Endocrinology]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
211833
EOID
654349
Map
0
LastModified
2012年8月28日(火) 22:02:31
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
堤 理恵
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Lawson Mark A
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Tsutsumi Rie
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Zhang Hao
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Talukdar Indrani
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Butler Brian K
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Santos Sharon J
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Mellon Pamela L
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Webster Nicholas J G
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2.

副題 任意
要約 任意

(英) The hypothalamic-pituitary-gonadal endocrine axis regulates reproduction through estrous phase-dependent release of the heterodimeric gonadotropic glycoprotein hormones, LH and FSH, from the gonadotropes of the anterior pituitary. Gonadotropin synthesis and release is dependent upon pulsatile stimulation by the hypothalamic neuropeptide GnRH. Alterations in pulse frequency and amplitude alter the relative levels of gonadotropin synthesis and release. The mechanism of interpretation of GnRH pulse frequency and amplitude by gonadotropes is not understood. We have examined gene expression in LbetaT2 gonadotropes under various pulse regimes in a cell perifusion system by microarray and identified 1127 genes activated by tonic or pulsatile GnRH. Distinct patterns of expression are associated with each pulse frequency, but the greatest changes occur at a 60-min or less interpulse interval. The immediate early gene mRNAs encoding early growth response (Egr)1 and Egr2, which activate the gonadotropin LH beta-subunit gene promoter, are stably induced at high pulse frequency. In contrast, mRNAs for the Egr corepressor genes Ngfi-A binding protein Nab1 and Nab2 are stably induced at low pulse frequency. We show that Ngfi-A binding protein members inhibit Egr-mediated frequency-dependent induction of the LH beta-subunit promoter. This pattern of expression suggests a model of pulse frequency detection that acts by suppressing activation by Egr family members at low frequency and allowing activation at sustained high-frequency pulses.

キーワード 推奨
  1. (英) Animals
  2. (英) Cell Division
  3. (英) Cells, Cultured
  4. (英) Early Growth Response Protein 1
  5. (英) Feedback
  6. (英) Gene Expression Profiling
  7. (英) Gene Expression Regulation
  8. (英) Kinetics
  9. (英) L Cells (Cell Line)
  10. (英) Luteinizing Hormone, beta Subunit
  11. (英) Mice
  12. (英) Promoter Regions, Genetic
  13. (英) RNA
  14. (英) Repressor Proteins
  15. (英) Reverse Transcriptase Polymerase Chain Reaction
  16. (英) Transfection
発行所 推奨
誌名 必須 Molecular Endocrinology([The Endocrine Society])
(pISSN: 0888-8809, eISSN: 1944-9917)
ISSN 任意 0888-8809
ISSN: 0888-8809 (pISSN: 0888-8809, eISSN: 1944-9917)
Title: Molecular endocrinology (Baltimore, Md.)
Title(ISO): Mol Endocrinol
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 21
必須 5
必須 1175 1191
都市 任意
年月日 必須 2007年 2月 13日
URL 任意
DOI 任意 10.1210/me.2006-0392    (→Scopusで検索)
PMID 任意 17299135    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Affiliation: Department of Reproductive Medicine 0674, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0674, USA. mlawson@ucsd.edu

  2. (英) PublicationType: Journal Article

  3. (英) PublicationType: Research Support, N.I.H., Extramural