著作: [堤 理恵]/Webster Nicholas J G/GnRH pulsatility, the pituitary response and reproductive dysfunction./[Endocrine Journal]
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種別 | 必須 | 総説·解説 | ||||||||||||||||||
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言語 | 必須 | 英語 | ||||||||||||||||||
招待 | 推奨 | |||||||||||||||||||
審査 | 推奨 | |||||||||||||||||||
カテゴリ | 推奨 | |||||||||||||||||||
共著種別 | 推奨 | |||||||||||||||||||
学究種別 | 推奨 | |||||||||||||||||||
組織 | 推奨 | |||||||||||||||||||
著者 | 必須 |
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題名 | 必須 |
(英) GnRH pulsatility, the pituitary response and reproductive dysfunction. |
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副題 | 任意 | |||||||||||||||||||
要約 | 任意 |
(英) GnRH plays an essential role in neuroendocrine control of reproductive function. In mammals, the pattern of gonadotropin secretion includes both pulse and surge phases, which are regulated independently. The pulsatile release of GnRH and LH plays an important role in the development of sexual function and in the normal regulation of the menstrual cycle. The importance of GnRH pulsatility was established in a series of classic studies. Fertility is impaired when GnRH pulsatility is inhibited by chronic malnutrition, excessive caloric expenditure, or aging. A number of reproductive disorders in women with including hypogonadotropic hypogonadism, hypothlamic amenorrhea, hyperprolactinemia and polycystic ovary syndrome (PCOS) are also associated with disruption of the normal pulsatile GnRH secretion. Despite these findings, the molecular mechanisms of this pulsatile GnRH regulation are not well understood. Here, we review recent studies about GnRH pulsatility, signaling and transcriptional response, and its implications for disease. |
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キーワード | 推奨 |
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発行所 | 推奨 | |||||||||||||||||||
誌名 | 必須 |
Endocrine Journal([社団法人 日本内分泌学会])
(pISSN: 0918-8959, eISSN: 1348-4540)
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巻 | 必須 | 56 | ||||||||||||||||||
号 | 必須 | 6 | ||||||||||||||||||
頁 | 必須 | 729 737 | ||||||||||||||||||
都市 | 任意 | |||||||||||||||||||
年月日 | 必須 | 2009年 7月 17日 | ||||||||||||||||||
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DOI | 任意 | 10.1507/endocrj.K09E-185 (→Scopusで検索) | ||||||||||||||||||
PMID | 任意 | 19609045 (→Scopusで検索) | ||||||||||||||||||
CRID | 任意 | |||||||||||||||||||
WOS | 任意 | 000271260300002 | ||||||||||||||||||
Scopus | 任意 | |||||||||||||||||||
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指導教員 | 推奨 | |||||||||||||||||||
備考 | 任意 |
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