著作: Terauchi Satsuki/[山本 武範]/[山下 菊治]/[片岡 正俊]/[寺田 弘]/[篠原 康雄]/Molecular basis of morphological changes in mitochondrial membrane accompanying induction of permeability transition, as revealed by immuno-electron microscopy./[Mitochondrion]
ヘルプを読む
「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)
- 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.
種別 | 必須 | 学術論文(審査論文) | |||
---|---|---|---|---|---|
言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Molecular basis of morphological changes in mitochondrial membrane accompanying induction of permeability transition, as revealed by immuno-electron microscopy. |
|||
副題 | 任意 | ||||
要約 | 任意 |
(英) The mitochondrial inner membrane typically shows a condensed structure when examined by electron microscopy. However, this typical structure is known to disappear upon induction of the mitochondrial permeability transition (PT). This change in the appearance of the mitochondrial membrane structure that accompanies the induction of PT is thought to reflect changes in the permeability of inner mitochondrial membrane; however, its molecular basis has remained uncertain. In the present study, changes in membrane status were examined by immuno-electron microscopy using antibodies against the voltage-dependent anion channel (VDAC), beta-subunit of F1-ATPase (F1beta), and cytochrome c (cyt. c). In control mitochondria, antibody against VDAC was observed at the rim of the mitochondria, whereas antibodies against F1beta and cytochrome c bound these molecules inside of the mitochondria. However, in PT-induced mitochondria, all three antibodies were observed at the mitochondrial rim. These results strongly suggest that the inner mitochondrial membrane is shoved to the rim region of mitochondria upon induction of mitochondrial PT. |
|||
キーワード | 推奨 |
|
|||
発行所 | 推奨 | ||||
誌名 | 必須 |
Mitochondrion(Mitochondria Research Society)
(pISSN: 1567-7249, eISSN: 1872-8278)
|
|||
巻 | 必須 | 5 | |||
号 | 必須 | 4 | |||
頁 | 必須 | 248 254 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2005年 8月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1016/j.mito.2005.04.002 (→Scopusで検索) | |||
PMID | 任意 | 16050987 (→Scopusで検索) | |||
CRID | 任意 | ||||
Scopus | 任意 | ||||
researchmap | 任意 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
|