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著作: Ogushi Y/Kitagawa D/[長谷川 敬展]/Suzuki M/Tanaka S/Correlation between aquaporin and water permeability in response to vasotocin, hydrin and {beta}-adrenergic effectors in the ventral pelvic skin of the tree frog Hyla japonica./[The Journal of Experimental Biology]

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EID
210780
EOID
697303
Map
0
LastModified
2013年7月29日(月) 15:31:03
Operator
松井 栄里
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Owner
長谷川 敬展
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Ogushi Y
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kitagawa D
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 長谷川 敬展([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Suzuki M
    役割 任意
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    学籍番号 推奨
  5. (英) Tanaka S
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Correlation between aquaporin and water permeability in response to vasotocin, hydrin and {beta}-adrenergic effectors in the ventral pelvic skin of the tree frog Hyla japonica.

副題 任意
要約 任意

(英) The ventral pelvic skin of the tree frog Hyla japonica expresses two kinds of arginine vasotocin (AVT)-stimulated aquaporins (AQP-h2 and AQP-h3), which affect the capacity of the frog's skin to absorb water. As such, it can be used as a model system for analyzing the molecular mechanisms of water permeability. We investigated AQP dynamics and water permeability in the pelvic skin of H. japonica following challenge with AVT, hydrins (intermediate peptides of pro-AVT) and beta-adrenergic effectors. In the in vivo experiment, both AQP-h2 and AQP-h3 proteins were translocated to the apical plasma membrane in the principal cells of the first-reacting cell (FRC) layer in the pelvic skin following challenge with AVT, hydrin 1 and hydrin 2, thereby increasing the water permeability of the pelvic skin. The beta-adrenergic receptor agonist isoproterenol (IP) and its anatagonist propranolol (PP) in combination with AVT or hydrins were used as challenge in the in vitro experiment. IP increased water permeability whereas PP inhibited it, and both events were well correlated with the translocation of the AQPs to the apical membrane. In the PP+AVT-treated skins, labels for AQP-h2 and AQP-h3 were differentially visible among the principal cells; the apical plasma membrane of some cells was labeled while others were not, indicating that the response of PP or AVT is different from cell to cell. These results provide morphological evidence that the principal cells of the FRC layers may have two kinds of receptors: a V2 receptor and beta-adrenergic receptor.

キーワード 推奨
  1. (英) Adrenergic beta-Agonists
  2. (英) Adrenergic beta-Antagonists
  3. (英) Animals
  4. (英) Anura
  5. (英) Aquaporins
  6. (英) Isoproterenol
  7. (英) Male
  8. (英) Permeability
  9. (英) Propranolol
  10. (英) Skin
  11. (英) Time Factors
  12. (英) Vasotocin
  13. (英) Water
発行所 推奨
誌名 必須 The Journal of Experimental Biology([The Company of Biologists Limited])
(pISSN: 0022-0949, eISSN: 1477-9145)
ISSN 任意 1477-9145
ISSN: 0022-0949 (pISSN: 0022-0949, eISSN: 1477-9145)
Title: The Journal of experimental biology
Title(ISO): J Exp Biol
Publisher: Company of Biologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 213
必須 2
必須 288 294
都市 任意
年月日 必須 2010年 1月 15日
URL 任意
DOI 任意 10.1242/jeb.036871    (→Scopusで検索)
PMID 任意 20038663    (→Scopusで検索)
CRID 任意
WOS 任意 000273041000017
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't